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Piribedil
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Catalog No. T3278Cas No. 3605-01-4
Alias Trivastan, Trivastal, EU-4200, ET-495
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
Piribedil
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Purity: 99.82%
Catalog No. T3278Alias Trivastan, Trivastal, EU-4200, ET-495Cas No. 3605-01-4
Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $35 | In Stock | In Stock | |
| 100 mg | $56 | In Stock | In Stock | |
| 500 mg | $156 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $40 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.82%
Color:White
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Product Introduction
Piribedil AI Summary
Piribedil demonstrates a diverse spectrum of bioactivities. It is potent in inhibiting the Menin-MLL interaction in MLL-related leukemias and affects several signaling pathways including NFkB, ERK, and mitochondrial processes. The compound modulates various enzymes and receptors, showing activity against acetylcholine muscarinic M1 receptor, USP2a, histone modifiers such as GCN5L2, G9a, Pin1, and binding affinity to receptors like DRD2, SLC6A2, ADRA2C, SLC6A4, DRD3, and HRH1. Additionally, it inhibits the transport activities of human BSEP, MRP2, MRP3, and MRP4.
In relation to safety, Piribedil is primarily associated with moderate liver toxicity, indicated by elevated levels of serum ALT, AST, and alkaline phosphatase, although there is no evidence of severe liver conditions like cirrhosis or malignancies.
The antiviral activities of Piribedil include inhibition of malarial parasites, Lassa and Ebola virus interactions, and SARS-CoV-2. Specifically, it shows some extent of inhibition on SARS-CoV-2 induced cytotoxicity in Vero E6 cells, although its effectiveness compared to the control arbidol is lower. The compound also shows a hit score indicative of low antiviral activity against SARS-CoV-2 in HRCE cells.
Moreover, Piribedil inhibits human HDAC6 with stronger effectiveness on certain substrates and engages with various receptors with both agonistic and antagonistic activities. Despite its varied bioactivity, its notable involvement includes effects on mitochondrial division, enzyme modulation, and receptor binding..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease. |
| Targets&IC50 | D2 receptor:6.9(pKi), α2A-adrenoceptor:7.1(pKi), α2C-adrenoceptor:7.2(pKi) |
| Synonyms | Trivastan, Trivastal, EU-4200, ET-495 |
| Molecular Weight | 298.34 |
| Formula | C16H18N4O2 |
| Cas No. | 3605-01-4 |
| Smiles | C(N1CCN(CC1)C1=NC=CC=N1)C1=CC2=C(OCO2)C=C1 |
| Relative Density. | 1.1183 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | Chloroform: Soluble DMSO: 18.33 mg/mL (61.44 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.7 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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