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Amatuximab (MORab-009) is a chimeric IgG1/k monoclonal antibody humanized against cell surface mesoleptin (MSLN) with antitumor activity for the treatment of solid tumors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 198.00 | |
5 mg | In stock | $ 538.00 | |
10 mg | In stock | $ 863.00 | |
25 mg | In stock | $ 1,290.00 | |
50 mg | In stock | $ 1,760.00 | |
100 mg | In stock | $ 2,380.00 |
Description | Amatuximab (MORab-009) is a chimeric IgG1/k monoclonal antibody humanized against cell surface mesoleptin (MSLN) with antitumor activity for the treatment of solid tumors. |
In vitro | Amatuximab (MORAb-009) is a murine-human chimeric monoclonal antibody with selective affinity for mesothelin (MSLN). In vitro, Amatuximab can induce antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cell lines expressing mesothelin and inhibit heterotypic cell adhesion between mesothelin-positive tumor cells and tumor cells expressing CA125[1]. |
In vivo | In tumor xenograft studies, the combination treatment of Amatuximab and chemotherapy significantly reduces the growth of mesothelin-expressing tumors to a greater extent compared to the use of Amatuximab or chemotherapy alone[1]. |
Synonyms | MORab-009 |
Molecular Weight | N/A |
CAS No. | 931402-35-6 |
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store at -20°C
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Amatuximab 931402-35-6 Others MORab-009 inhibitor inhibit