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Amatuximab
(Synonyms: MORab-009) Copy Product Info
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Synonyms: MORab-009
Catalog No. T76671 Copy Product Info
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Amatuximab (MORab-009) is a humanized chimeric IgG1/k monoclonal antibody targeting cell surface mesothelin (MSLN) with antitumor activity for the treatment of solid tumors.
Cas No. 931402-35-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | In Stock | In Stock | |
| 5 mg | $538 | In Stock | In Stock | |
| 10 mg | $863 | - | In Stock | |
| 25 mg | $1,290 | - | In Stock | |
| 50 mg | $1,760 | - | In Stock | |
| 100 mg | $2,380 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.2% (SDS-PAGE); 98.4% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Antigen Details
Chemical Properties
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| Description | Amatuximab (MORab-009) is a humanized chimeric IgG1/k monoclonal antibody targeting cell surface mesothelin (MSLN) with antitumor activity for the treatment of solid tumors. |
| In vitro | Amatuximab (MORAb-009) is a murine-human chimeric monoclonal antibody with selective affinity for mesothelin (MSLN). In vitro, Amatuximab can induce antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cell lines expressing mesothelin and inhibit heterotypic cell adhesion between mesothelin-positive tumor cells and tumor cells expressing CA125[1]. |
| In vivo | In tumor xenograft studies, the combination treatment of Amatuximab and chemotherapy significantly reduces the growth of mesothelin-expressing tumors to a greater extent compared to the use of Amatuximab or chemotherapy alone[1]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | MORab-009 |
| Reactivity | Human |
| Verified Activity | Immobilized Human MSLN/Mesothelin Protein (His) (TMPY-07107) at 1 μg/mL (100 μL/well) can bind Amatuximab. The EC50 is 3.40 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Mesothelin |
| Molecular Weight | 144.31 kDa |
| Cas No. | 931402-35-6 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Amatuximab chemical structure | Amatuximab in vivo | Amatuximab in vitro | Amatuximab molecular weight
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