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Bentiromide

Name: Bentiromide
Brand: TargetMol
SKU: T14529
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14529Cas No. 37106-97-1

Bentiromide is a peptide used in the bentiromide test to monitor the adequacy of supplemental pancreatic therapy and to screen exocrine pancreatic insufficiency.

Bentiromide

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Purity: 99.89%

Catalog No. T14529Cas No. 37106-97-1

Bentiromide is a peptide used in the bentiromide test to monitor the adequacy of supplemental pancreatic therapy and to screen exocrine pancreatic insufficiency.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$42	In Stock	In Stock
10 mg	$62	In Stock	In Stock
50 mg	$95	In Stock	In Stock
100 mg	$156	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bentiromide AI Summary

Bentiromide exhibits multiple pharmacological activities. It inhibits human BSEP (bile salt export pump) with an IC50 value of 234800.0 nM, demonstrated through decreased ATP-dependent [3H]-taurocholate transport in baculovirus-transfected fall armyworm Sf21 cell membranes. The compound shows antiviral activity against SARS-CoV-2, with a 3.69% inhibition rate of virus-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours, a hit score of 0.2686 in HRCE cells when measured by imaging at MOI 0.4 after 96 hours, and a 0.12% inhibition rate in VERO-6 cells at 10 µM after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 16.62% at 20 µM, indicating its potential as a protease inhibitor. Bentiromide also shows 10.59% and 3.32% inhibition of human HDAC6 in assays with commercial and custom peptide substrates, respectively. Moreover, it binds to a variety of human receptors with AC50 values greater than 10,000.0 nM, indicating moderate to weak binding affinity and lacks significant inhibitory activity in several enzyme assays. It displays both agonist and antagonist activities at certain receptors, demonstrating a broad but moderate interaction profile across various biological targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Bentiromide is a peptide used in the bentiromide test to monitor the adequacy of supplemental pancreatic therapy and to screen exocrine pancreatic insufficiency.

Chemical Properties

Molecular Weight	404.42
Formula	C₂₃H₂₀N₂O₅
Cas No.	37106-97-1
Smiles	OC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)c2ccccc2)cc1
Relative Density.	1.367g/cm3
Sequence	Bz-Tyr-4Abz-OH
Sequence Short	YX

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (618.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4727 mL	12.3634 mL	24.7268 mL	123.6338 mL
5 mM	0.4945 mL	2.4727 mL	4.9454 mL	24.7268 mL
10 mM	0.2473 mL	1.2363 mL	2.4727 mL	12.3634 mL
20 mM	0.1236 mL	0.6182 mL	1.2363 mL	6.1817 mL
50 mM	0.0495 mL	0.2473 mL	0.4945 mL	2.4727 mL
100 mM	0.0247 mL	0.1236 mL	0.2473 mL	1.2363 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc