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LEESGGGLVQPGGSMK

Name: LEESGGGLVQPGGSMK
Brand: TargetMol
SKU: T39521
Rating: 4.5 (1 reviews)

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Catalog No. T39521Cas No. 2096980-79-7

LEESGGGLVQPGGSMK, a proteolysis peptide, is a component of Infliximab, a chimeric monoclonal IgG1 antibody that selectively binds to TNF-α. It is used for the quantitative assessment of Infliximab.

LEESGGGLVQPGGSMK

😃Good

Catalog No. T39521Cas No. 2096980-79-7

LEESGGGLVQPGGSMK, a proteolysis peptide, is a component of Infliximab, a chimeric monoclonal IgG1 antibody that selectively binds to TNF-α. It is used for the quantitative assessment of Infliximab.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

LEESGGGLVQPGGSMK, a proteolysis peptide, is a component of Infliximab, a chimeric monoclonal IgG1 antibody that selectively binds to TNF-α. It is used for the quantitative assessment of Infliximab.

In vitro

Anti-TNF antibodies, which block TNF alpha action, have transformed the treatment of TNF-related diseases, including Inflammatory Bowel Disease, lupus, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis. By neutralizing TNF activity, these antibodies not only facilitate mucosal healing but also induce long-term remissions in vivo. The primary anti-TNF antibodies approved for use are Infliximab, Etanercept, Adalimumab, Certolizumab, and Golimumab[1].

Chemical Properties

Molecular Weight	1545.73
Formula	C₆₄H₁₀₈N₁₈O₂₄S
Cas No.	2096980-79-7
Smiles	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O \|@@:92\|
Relative Density.	1.334 g/cm3 (Predicted)
Sequence	Leu-Glu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Met-Lys
Sequence Short	LEESGGGLVQPGGSMK

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc