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AVP-13358
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Catalog No. T30231Cas No. 459805-03-9
AVP-13358 is a CD23 antagonist (immunoglobulin ε-Fc receptor antagonist), an immunoglobulin E inhibitor. AVP-13358 has potent activity against IgE, cytokines and CD23 and is used in the treatment of immune system disorders, infections and otolaryngological disorders.
AVP-13358
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Purity: 98.45%
Catalog No. T30231Cas No. 459805-03-9
AVP-13358 is a CD23 antagonist (immunoglobulin ε-Fc receptor antagonist), an immunoglobulin E inhibitor. AVP-13358 has potent activity against IgE, cytokines and CD23 and is used in the treatment of immune system disorders, infections and otolaryngological disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $210 | In Stock | In Stock | |
| 5 mg | $497 | In Stock | In Stock | |
| 10 mg | $678 | In Stock | In Stock | |
| 25 mg | $953 | In Stock | In Stock | |
| 50 mg | $1,180 | In Stock | In Stock | |
| 100 mg | $1,500 | In Stock | In Stock | |
| 200 mg | $1,960 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.45%
Appearance:Solid
Color:White
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Product Introduction
AVP-13358 AI Summary
AVP-13358 exhibits a range of significant bioactivities and pharmacokinetic properties. It shows potent inhibition of IgE production, demonstrated ex vivo in spleen cells from antigen-sensitized BALB/c mice with an IC50 of 3.0 nM, and in B lymphocytes from BALB/c mice with an IC50 of 8.0 nM. Additionally, it inhibits the production of cytokines IL4, IL5, and IL13 in ConA and anti-CD3 antibody-sensitized BALB/c mouse spleen T lymphocytes, each with IC50 values of 30.0 nM. It also effectively suppresses CD23 expression in IL4 and anti-CD3 antibody-sensitized CD14-positive human peripheral blood lymphocytes and mouse splenocytes with IC50 values of 20.0 nM and 40.0 nM, respectively, as well as IL4 receptor alpha expression in mouse splenocytes at an IC50 of 100.0 nM.
Moreover, AVP-13358 exhibits antiviral activity against HSV2, vaccinia virus, California encephalitis virus, San Angelo virus, mouse hepatitis virus, Modoc virus, and Rhinovirus-infected cells with IC50 values ranging from 20.0 nM to 300.0 nM. It also shows a favorable selectivity ratio of IC50 values for HSV2-infected and vaccinia virus-infected Vero cells compared to IgE production inhibition.
Pharmacokinetically, AVP-13358 has high plasma protein binding at 99.7%, a high octan-1-ol/water distribution coefficient (LogD7.4 value of 4.24), and demonstrates high intrinsic clearance in human liver microsomes (146.0 mL.min^-1.g^-1). These properties suggest efficient liver clearance, good cellular permeability, and overall favorable pharmacokinetic characteristics. Overall, AVP-13358 presents promising potential due to its multifaceted bioactivities, particularly in antiviral effects and inhibition of IgE production..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AVP-13358 is a CD23 antagonist (immunoglobulin ε-Fc receptor antagonist), an immunoglobulin E inhibitor. AVP-13358 has potent activity against IgE, cytokines and CD23 and is used in the treatment of immune system disorders, infections and otolaryngological disorders. |
| Molecular Weight | 491.58 |
| Formula | C30H29N5O2 |
| Cas No. | 459805-03-9 |
| Smiles | C(NC1=CC=C(C=C1)C=2NC=3C(N2)=CC=C(C(NC4=CC=CC=N4)=O)C3)(=O)C56CC7CC(C5)CC(C6)C7 |
| Relative Density. | 1.38 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7 mg/mL (14.24 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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