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CWI1-2

Name: CWI1-2
Brand: TargetMol
SKU: T67930
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67930Cas No. 2408590-36-1

CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.

CWI1-2

🥰Excellent

Purity: 98.27%

Catalog No. T67930Cas No. 2408590-36-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$645	-	In Stock
200 mg	$887	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.27%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.
In vitro	CWI1-2 demonstrates excellent anti-leukemia efficacy in a concentration range of 0-1 μM for 24 hours[1].
In vivo	Administered intravenously at 5 mg/kg once daily for 7-10 days, CWI1-2 significantly delays the onset of leukemia and extends the survival time in BMT (bone marrow transplantation) recipient B6.SJL (CD45.1) mice, with no apparent impact on body weight[1].

Chemical Properties

Molecular Weight	519.77
Formula	C₂₂H₁₇Cl₃N₆O₃
Cas No.	2408590-36-1
Smiles	ClC1=CC=C(O)C(C=NN=C(NN=CC2=CC(Cl)=CC=C2O)NN=CC3=CC(Cl)=CC=C3O)=C1
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (173.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9239 mL	9.6196 mL	19.2393 mL	96.1964 mL
5 mM	0.3848 mL	1.9239 mL	3.8479 mL	19.2393 mL
10 mM	0.1924 mL	0.9620 mL	1.9239 mL	9.6196 mL
20 mM	0.0962 mL	0.4810 mL	0.9620 mL	4.8098 mL
50 mM	0.0385 mL	0.1924 mL	0.3848 mL	1.9239 mL
100 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.9620 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc