Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 44.00 | |
5 mg | Inquiry | $ 105.00 | |
10 mg | Inquiry | $ 178.00 | |
25 mg | Inquiry | $ 396.00 | |
50 mg | Inquiry | $ 645.00 | |
100 mg | Inquiry | $ 987.00 | |
500 mg | Inquiry | $ 1,980.00 |
Description | CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation. |
In vitro | CWI1-2 demonstrates excellent anti-leukemia efficacy in a concentration range of 0-1 μM for 24 hours[1]. |
In vivo | Administered intravenously at 5 mg/kg once daily for 7-10 days, CWI1-2 significantly delays the onset of leukemia and extends the survival time in BMT (bone marrow transplantation) recipient B6.SJL (CD45.1) mice, with no apparent impact on body weight[1]. |
Molecular Weight | 519.77 |
Formula | C22H17Cl3N6O3 |
CAS No. | 2408590-36-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (173.15 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CWI1-2 2408590-36-1 Apoptosis CWI12 inhibitor inhibit