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Anti-NKCC1/SLC12A2 Polyclonal Antibody
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Catalog No. TMAB-09494
Anti-NKCC1/SLC12A2 Polyclonal Antibody is a Rabbit antibody targeting NKCC1/SLC12A2. Anti-NKCC1/SLC12A2 Polyclonal Antibody can be used in FCM.
Anti-NKCC1/SLC12A2 Polyclonal Antibody
Anti-NKCC1/SLC12A2 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-09494
Anti-NKCC1/SLC12A2 Polyclonal Antibody is a Rabbit antibody targeting NKCC1/SLC12A2. Anti-NKCC1/SLC12A2 Polyclonal Antibody can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-NKCC1/SLC12A2 Polyclonal Antibody is a Rabbit antibody targeting NKCC1/SLC12A2. Anti-NKCC1/SLC12A2 Polyclonal Antibody can be used in FCM. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Chimpanzee) |
| Verified Activity | Blank control: A549. Primary Antibody (green line): Rabbit Anti-SLC12A2 antibody (TMAB-09494) Dilution: 3 μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG. Secondary Antibody: Goat anti-rabbit IgG-PE Dilution: 3 μg /test. Protocol The cells were incubated in 5% BSA to block non-specific protein-protein interactions for 30 min at at room temperature. Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. |
| Application | |
| Recommended Dose | FCM: 3μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in many tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome. |
| Immunogen | KLH conjugated synthetic peptide: human NKCC1 |
| Antigen Species | Human |
| Gene Name | SLC12A2 |
| Gene ID | |
| Protein Name | Solute carrier family 12 member 2 |
| Uniprot ID | |
| Function | Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. |
| Molecular Weight | Theoretical: 132 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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