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ART-CHEM-BB B025267

Name: ART-CHEM-BB B025267
Brand: TargetMol
SKU: T9821
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9821Cas No. 381208-40-8

ART-CHEM-BB B025267 is the upregulator of utrophin production with EC50 of 1.8 μM and can be used in research on the treatment of Duchenne muscular dystrophy.

ART-CHEM-BB B025267

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Purity: 99.19%

Catalog No. T9821Cas No. 381208-40-8

ART-CHEM-BB B025267 is the upregulator of utrophin production with EC50 of 1.8 μM and can be used in research on the treatment of Duchenne muscular dystrophy.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	In Stock	In Stock
5 mg	$183	In Stock	In Stock
10 mg	$272	In Stock	In Stock
25 mg	$413	In Stock	In Stock
50 mg	$580	In Stock	In Stock
100 mg	$777	In Stock	In Stock
200 mg	$1,030	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$175	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.19%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

ART-CHEM-BB B025267 AI Summary

ART-CHEM-BB B025267 activates the UTRN promoter in mouse H2K cells, leading to the upregulation of utrophin transcription as measured by a luciferase reporter assay, with an EC50 value of 1800.0 nM. It also exhibits significant antiviral activity against SARS-CoV-2 by inhibiting the virus-induced cytotoxicity in Caco-2 and VERO-6 cells at a concentration of 10 µM, showing inhibition rates of -5.9% and 0.32% respectively. Additionally, the compound demonstrates a potent inhibitory effect on the SARS-CoV-2 3CL-Pro protease, with a -94.47% inhibition at 20 µM. Lastly, ART-CHEM-BB B025267 shows strong activity as a human HDAC6 inhibitor, evidenced by 97.24% inhibition in an enzymatic assay with a commercial peptide substrate, 37.17% inhibition with a custom peptide substrate, and a high inhibition rate of 99.95% in hit confirmation using a custom peptide substrate, with an IC50 value of 527.9 nM. Thus, ART-CHEM-BB B025267 shows potential utility in both antiviral and HDAC6 inhibition therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ART-CHEM-BB B025267 is the upregulator of utrophin production with EC50 of 1.8 μM and can be used in research on the treatment of Duchenne muscular dystrophy.
Targets&IC50	Utrophin:1.8 μM (EC50)

Chemical Properties

Molecular Weight	295.38
Formula	C₁₇H₂₁N₅
Cas No.	381208-40-8
Smiles	CCN(CC)C1=CC=C(C=C1)N1N=C2C=C(C)C(N)=CC2=N1
Relative Density.	1.20 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (186.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3855 mL	16.9273 mL	33.8547 mL	169.2735 mL
5 mM	0.6771 mL	3.3855 mL	6.7709 mL	33.8547 mL
10 mM	0.3385 mL	1.6927 mL	3.3855 mL	16.9273 mL
20 mM	0.1693 mL	0.8464 mL	1.6927 mL	8.4637 mL
50 mM	0.0677 mL	0.3385 mL	0.6771 mL	3.3855 mL
100 mM	0.0339 mL	0.1693 mL	0.3385 mL	1.6927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc