CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 487.00 | |
500 μg | 5 days | $ 1,950.00 | |
1 mg | 5 days | $ 3,250.00 |
Description | CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. |
Species | Cynomolgus |
Expression System | HEK293 |
Tag | C-mFc |
Accession Number | A0A8J8XUI3 |
Synonyms | GPR-CY6, CY6, CKRL1, CDw198, CMKBR8, ChemR1, CKR-L1, CD198, CCR-8, TER-1, CCR8, CMKBRL2, TER1, GPRCY6 |
Construction | Recombinant Cynomolgus CCR8 Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus. It contains Met1-Lys35.[Accession |XP_015300839.1] |
Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
Molecular Weight | The protein has a predicted MW of 29.73 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability & Storage |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. |
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Please read the User Guide of Recombinant Proteins for more specific information.
CCR8 Protein, Cynomolgus, Recombinant (mFc) CMKBRL-2 GPR-CY6 TER 1 CD-198 CY6 CKRL1 CDw198 CY 6 GPRCY-6 CKRL-1 CMKBR8 CD 198 ChemR1 CMKBR-8 CMKBRL 2 CKR-L1 CD198 CY-6 GPRCY 6 CKRL 1 CCR-8 CCR 8 TER-1 CCR8 CMKBR 8 CMKBRL2 TER1 GPRCY6 recombinant recombinant-proteins proteins protein