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Boc-NH-PEG10-NHS ester is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.
Description | Boc-NH-PEG10-NHS ester is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells. |
In vitro | PROTACs, consisting of two ligands linked together—one binding to an E3 ubiquitin ligase and the other to a target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 726.81 |
Formula | C32H58N2O16 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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