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Anti-Serpin D1 Antibody (6A450)
😃Good
Catalog No. TMAY-00572
Alias Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900
Anti-Serpin D1 Antibody (6A450) is a Mouse antibody targeting Serpin D1. Anti-Serpin D1 Antibody (6A450) can be used in IHC-P.
Anti-Serpin D1 Antibody (6A450)
Anti-Serpin D1 Antibody (6A450)
😃Good
Catalog No. TMAY-00572Alias Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900
Anti-Serpin D1 Antibody (6A450) is a Mouse antibody targeting Serpin D1. Anti-Serpin D1 Antibody (6A450) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900 |
| Ig Type | Mouse IgG1 |
| Clone | 6A450 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human serpinD1 in human liver with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte. 2. Immunochemical staining of human serpinD1 in human hepatoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinD1 (rh SerpinD1; TMPY-00917; NP_000176.2; Met1-Ser499). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human SerpinD1 protein (TMPY-00917) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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