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Anti-Serpin D1 Antibody (6A450)

😃Good
Catalog No. TMAY-00572
Alias Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900

Anti-Serpin D1 Antibody (6A450) is a Mouse antibody targeting Serpin D1. Anti-Serpin D1 Antibody (6A450) can be used in IHC-P.

Anti-Serpin D1 Antibody (6A450)

Anti-Serpin D1 Antibody (6A450)

😃Good
Catalog No. TMAY-00572Alias Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900
Anti-Serpin D1 Antibody (6A450) is a Mouse antibody targeting Serpin D1. Anti-Serpin D1 Antibody (6A450) can be used in IHC-P.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Serpin D1 Antibody (6A450) is a Mouse antibody targeting Serpin D1. Anti-Serpin D1 Antibody (6A450) can be used in IHC-P.
AliasSerpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900
Ig Type
Monoclonal Mouse IgG1
Clone
6A450
Reactivity
Human
Verified Activity
1. Immunochemical staining of human serpinD1 in human liver with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.

2. Immunochemical staining of human serpinD1 in human hepatoma with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.
Application
IHC-P
Recommended Dose
IHC-P: 1:50-1:200
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinD1 (rh SerpinD1; TMPY-00917; NP_000176.2; Met1-Ser499). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundSerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human SerpinD1 protein (TMPY-00917)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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