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Flunarizine dihydrochloride

Name: Flunarizine dihydrochloride
Brand: TargetMol
SKU: T0806
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0806Cas No. 30484-77-6

Alias R14950, KW-3149, Flunarizine 2HCl

Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

Flunarizine dihydrochloride

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Purity: 99.99%

Catalog No. T0806Alias R14950, KW-3149, Flunarizine 2HClCas No. 30484-77-6

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$60	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Flunarizine dihydrochloride AI Summary

Flunarizine dihydrochloride shows a broad range of bioactivities. It exhibits binding affinity to opioid receptors with IC50 values of 2410.0 nM (mu), 9480.0 nM (kappa 1), and 3630.0 nM (delta), suggesting its potential as an opioid receptor modulator. It demonstrates antiplasmodial activity against Plasmodium falciparum, with IC50 values between 3981.07 nM and 12589.25 nM, indicating a moderate to potent inhibitory effect on malaria parasites. In addition to its antiplasmodial properties, Flunarizine dihydrochloride shows activity in a wide array of assays, including modulation of Lamin A splicing (IC50: 22387.2 nM), erasure of genomic imprints (IC50: 15848.9 nM), identification of novel anesthetics (IC50: 44668.4 nM), and inhibition of Influenza NS1 Protein Function (IC50: 28183.8 nM). Furthermore, it inhibits various viral and cellular targets, including SARS-CoV-2 3CL-Pro protease by 7.028% at 20 µM, SARS-CoV-2 induced cytotoxicity in Caco-2 and Vero-6 cells, and shows cytotoxicity in HepG2 cells (IC50: 14600.0 nM). Flunarizine dihydrochloride also displays high inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at 10 µM concentration, suggesting potential transporter interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Flunarizine dihydrochloride (R14950) is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine dihydrochloride (R14950) is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Targets&IC50	Ca2+ channel:68 nM(Ki)
Synonyms	R14950, KW-3149, Flunarizine 2HCl

Chemical Properties

Molecular Weight	477.42
Formula	C₂₆H₂₈Cl₂F₂N₂
Cas No.	30484-77-6
Smiles	Cl.Fc1ccc(cc1)C(N1CCN(C/C=C/c2ccccc2)CC1)c1ccc(F)cc1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2.4 mg/mL (5.03 mM), Sonication is recommended.

DMSO: 50 mg/mL (104.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0946 mL	10.4730 mL	20.9459 mL	104.7296 mL
5 mM	0.4189 mL	2.0946 mL	4.1892 mL	20.9459 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2095 mL	1.0473 mL	2.0946 mL	10.4730 mL
20 mM	0.1047 mL	0.5236 mL	1.0473 mL	5.2365 mL
50 mM	0.0419 mL	0.2095 mL	0.4189 mL	2.0946 mL
100 mM	0.0209 mL	0.1047 mL	0.2095 mL	1.0473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc