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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

Complement System

The complement system, also known as complement cascade, is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. It is part of the innate immune system, which is not adaptable and does not change during an individual's lifetime. The complement system can, however, be recruited and brought into action by antibodies generated by the adaptive immune system.

Filter HomeSignaling PathwaysImmunology/InflammationComplement System

Iptacopan hydrochloride

T91891646321-63-2In house

Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.

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Cyclosporin A

T094559865-13-3

Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).

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Dexamethasone

T107650-02-2

Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.

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AMY-101 acetate

T64692

AMY-101 acetate (Cp40 acetate) is a cyclic peptide, an inhibitor of C3 Complement and an immunomodulator used in the treatment of gingivitis and periodontitis, which significantly reduces inflammation and lowers MMP-8 and MMP-9 levels.AMY-101 acetate also have a palliative effect on covid -19-induced lung inflammation injury and SARS-COV-2-related acute kidney injury in patients with acute respiratory distress syndrome (ARDS).

$297

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JR14a

T93162411440-41-8

JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.

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Lipoteichoic acid

T4064656411-57-5

Lipoteichoic acid, a polymer of the cell wall of gram-positive bacteria, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway.

$196

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SB290157 trifluoroacetate

T128511140525-25-2

SB290157 trifluoroacetate is a potent and selective antagonist of the C3a receptor, with an IC50 of 200 nM.

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Factor B-IN-5

T62689L2797066-85-2

Factor B-IN-5 is a complement factor B inhibitor, which can be used to study immune-related diseases.

$126

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Complement factor D-IN-2

T383321903742-34-6

Complement factor D-IN-2 is an inhibitor that reduces the excessive activation of Complement factor D.

$113

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Avacopan

T82231346623-17-3

Avacopan (CCX168) is a C5aR antagonist (IC50=0.1 nM) with selective and oral activity. Avacopan blocks the action of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a mouse model of AAV. Avacopan can be used to treat anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis.

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Sutimlimab

T767022049079-64-1

Sutimlimab is a novel monoclonal antibody targeting complement protein C1. Sutimlimab is commonly used as a C1 inhibitor to treat cold agglutina-associated hemolysis.

$208

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EG01377 2HCl

T11154L2749438-61-5In house

EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities.

$123

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Compstatin

TP1304206645-99-0

Compstatin is a cyclic peptide consisting of 13 amino acid residues and is a potent inhibitor of complement system C3. Compstatin is species-specific and has inhibitory effects only on the complement system of primates. Studies have shown that it can bind to baboon C3 and is resistant to proteolytic cleavage in baboon blood. Its IC50 values for the classical pathway and alternative pathway are 63 μM and 12 μM, respectively.

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C3a Receptor Agonist

T38287944997-60-8

C3a Receptor Agonist (C3a receptor agonist 1) binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.

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BCX 1470 hydrochloride

T13568L In house

BCX 1470 hydrochloride is a potent serine protease inhibitor with anti-inflammatory activity that inhibits the ester hydrolysis and haemolytic activity of factor D and C1s, and can be used to study oedema.

$139

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PMX 53 acetate(219639-75-5 free base)

TP2334852629-88-0

PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).

$113

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Danicopan

T85091903768-17-1

Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

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Complement C5-IN-1

T108632365402-67-9In house

Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).

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Pozelimab

T771212096328-94-6

Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.

$328

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PMX 205 acetate(514814-49-4 free base)

T12506L1

PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).

$113

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Eculizumab

T9915219685-50-4

Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5

$179

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Tesidolumab

T768311531594-08-7

Tesidolumab (LFG316) is a fully human IgG1 λ anti-C5 monoclonal antibody. Tesidolumab (LFG316) has an inhibitory effect on crovalimab and C5, blocking the cutting of C5 and preventing the subsequent formation of membrane attack complex, which can be used to study extravascular hemolysis.

$198

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LEP(116-130)(mouse)TFA(258276-95-8 free base)

TP1305L

LEP(116-130)(mouse) is a synthetic leptin peptide fragment.

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W-54011

T17250405098-33-1

W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophi

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