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Anti-Prostatic Acid Phosphatase Antibody (4N895)
😃Good
Catalog No. TMAY-01378
Alias Ppal, PAP, Lap, FRAP, acid phosphatase, prostate, A030005E02Rik, 9.104100899-104272570.1, 5'-NT
Anti-Prostatic Acid Phosphatase Antibody (4N895) is a Mouse antibody targeting Prostatic Acid Phosphatase. Anti-Prostatic Acid Phosphatase Antibody (4N895) can be used in ELISA.
Anti-Prostatic Acid Phosphatase Antibody (4N895)
Anti-Prostatic Acid Phosphatase Antibody (4N895)
😃Good
Catalog No. TMAY-01378Alias Ppal, PAP, Lap, FRAP, acid phosphatase, prostate, A030005E02Rik, 9.104100899-104272570.1, 5'-NT
Anti-Prostatic Acid Phosphatase Antibody (4N895) is a Mouse antibody targeting Prostatic Acid Phosphatase. Anti-Prostatic Acid Phosphatase Antibody (4N895) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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| Description | Anti-Prostatic Acid Phosphatase Antibody (4N895) is a Mouse antibody targeting Prostatic Acid Phosphatase. Anti-Prostatic Acid Phosphatase Antibody (4N895) can be used in ELISA. |
| Alias | Ppal, PAP, Lap, FRAP, acid phosphatase, prostate, A030005E02Rik, 9.104100899-104272570.1, 5'-NT |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4N895 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Prostatic Acid Phosphatase / ACPP (rh Prostatic Acid Phosphatase / ACPP; TMPY-02155; NP_001127666.1; Met 1-Lys 382). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase is synthesized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Prostatic Acid Phosphatase / ACPP protein (TMPY-02155) |
| Antigen Species | Human |
| Biology Area | Phosphatases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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