Shopping Cart

Your shopping cart is currently empty

LY 78335

Name: LY 78335
Brand: TargetMol
SKU: T22956
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T22956Cas No. 39959-66-5

Alias 1-(2,3-Dichlorophenyl)ethanamine hydrochloride

LY 78335 (1-(2,3-Dichlorophenyl)ethanamine hydrochloride) is a phenylethanolamine-N-methyltransferase (PNMT) inhibitor.

LY 78335

Copy Product Info

🥰Excellent

Purity: 99.81%

Catalog No. T22956Alias 1-(2,3-Dichlorophenyl)ethanamine hydrochlorideCas No. 39959-66-5

LY 78335 (1-(2,3-Dichlorophenyl)ethanamine hydrochloride) is a phenylethanolamine-N-methyltransferase (PNMT) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$173	In Stock	In Stock
50 mg	$273	In Stock	In Stock
100 mg	$394	In Stock	In Stock
200 mg	$573	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.81%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

LY 78335 AI Summary

LY 78335 exhibits a broad spectrum of bioactivities, primarily noted for its antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 7943.28 nM to 12589.25 nM as determined by the SYBR green assay over 72 hours. It also demonstrates differential inhibitory effects on Plasmodium falciparum proliferation, with potencies from 7943.3 nM to 11220.2 nM. Additionally, LY 78335 inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with an IC50 of 17782.8 nM and human alpha-Galactosidase at 10000.0 nM. It further inhibits lipid storage modulators and N370S glucocerebrosidase with potencies of 39810.7 nM. The compound is also active against Histone Lysine Methyltransferase G9a (3162.3 nM), Polymerase Iota (100000.0 nM), and exhibits activity against Marburg Virus at 4466.8 nM by inhibiting its binding or entry into cells. Additionally, it inhibits the human recombinant PNMT enzyme by 60.0% in a fluorescence-based assay using AdoMet and DL-norepinephrine hydrochloride as substrates after a preincubation period of 30 minutes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	LY 78335 (1-(2,3-Dichlorophenyl)ethanamine hydrochloride) is a phenylethanolamine-N-methyltransferase (PNMT) inhibitor.
Synonyms	1-(2,3-Dichlorophenyl)ethanamine hydrochloride

Chemical Properties

Molecular Weight	226.53
Formula	C₈H₁₀Cl₃N
Cas No.	39959-66-5
Smiles	Cl.CC(N)c1cccc(Cl)c1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (220.72 mM), Sonication is recommended.

H2O: < 25 mg/mL (110.36 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4144 mL	22.0721 mL	44.1443 mL	220.7213 mL
5 mM	0.8829 mL	4.4144 mL	8.8289 mL	44.1443 mL
10 mM	0.4414 mL	2.2072 mL	4.4144 mL	22.0721 mL
20 mM	0.2207 mL	1.1036 mL	2.2072 mL	11.0361 mL
50 mM	0.0883 mL	0.4414 mL	0.8829 mL	4.4144 mL
100 mM	0.0441 mL	0.2207 mL	0.4414 mL	2.2072 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc