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Hippuric acid

Name: Hippuric acid
Brand: TargetMol
SKU: T4815
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4815Cas No. 495-69-2

Alias Benzoylglycine, 2-Benzamidoacetic acid

Hippuric acid (2-Benzamidoacetic acid) is an acyl glycine formed by the conjugation of benzoic acid with glycine. Hippuric acid) is a normal component of urine and is typically increased with increased consumption of phenolic compounds (tea, wine, fruit juices). These phenols are converted to benzoic acid which is then converted to hippuric acid and excreted in the urine.

Hippuric acid

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Purity: 99.35%

Catalog No. T4815Alias Benzoylglycine, 2-Benzamidoacetic acidCas No. 495-69-2

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$42	In Stock	In Stock
5 g	$50	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.35%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Hippuric acid AI Summary

Hippuric acid demonstrates a diverse range of bioactivities and physicochemical properties. The compound has a bitter taste with a bitterness threshold of Log 1/T = 2.3 and a partition coefficient (logP) of -1.99, indicating low lipophilicity. It shows no drug release in lysozyme-conjugated prodrugs under in vitro stability tests at pH 5 and pH 7.4. Hippuric acid is an aldose reductase inhibitor with an IC50 value of approximately 330,000 nM in rat lens and exhibits inhibition of mouse organic anion transporters Oat1 and Oat6, with Ki values around 55,600 nM for Oat1 and 309,029 nM for Oat6, respectively. Additionally, it acts as a histone deacetylase (HDAC) inhibitor in human Hela cells, achieving 100% inhibition at a concentration of 500 µM. It also exhibits multiple bioactivities, including modulating Lamin A splicing (potency 316.2 nM), inhibiting lipid storage in Drosophila S3 cells (potency 58.0 nM), and blocking the interaction between CBF-beta and RUNX1 for acute myeloid leukemia (potency 3548.1 nM). It shows delayed death inhibition of the malarial parasite plastid (IC50 8275.3 nM), TGF-b inhibition (IC50 6309.6 nM), and Ebola virus entry blocking (AC50 3162.3 nM and 3.162 µM). For SARS-CoV-2, it inhibits the virus-induced cytotoxicity of VERO-6 cells and has an inhibitory effect on the 3CL-Pro protease by 8.931% at 20 µM. It shows low activity against cell viability in Vero E6 cells infected with the virus. Hippuric acid also inhibits human dihydrofolate reductase (DHFR) with a high inhibition constant (Ki) of 17,000,000 nM and exhibits inhibitory activity in enzymatic assays of human HDAC6. Lastly, it has potential transporter interactions, inhibiting the uptake of compounds like PAH and Indoxyl sulfate in various OAT-expressing models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hippuric acid (2-Benzamidoacetic acid) is an acyl glycine formed by the conjugation of benzoic acid with glycine. Hippuric acid) is a normal component of urine and is typically increased with increased consumption of phenolic compounds (tea, wine, fruit juices). These phenols are converted to benzoic acid which is then converted to hippuric acid and excreted in the urine.
Synonyms	Benzoylglycine, 2-Benzamidoacetic acid

Chemical Properties

Molecular Weight	179.17
Formula	C₉H₉NO₃
Cas No.	495-69-2
Smiles	OC(=O)CNC(=O)C1=CC=CC=C1
Relative Density.	1.371 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (139.53 mM), Sonication is recommended.

H2O: 2.5 mg/mL (13.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (18.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5813 mL	27.9065 mL	55.8129 mL	279.0646 mL
5 mM	1.1163 mL	5.5813 mL	11.1626 mL	55.8129 mL
10 mM	0.5581 mL	2.7906 mL	5.5813 mL	27.9065 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2791 mL	1.3953 mL	2.7906 mL	13.9532 mL
50 mM	0.1116 mL	0.5581 mL	1.1163 mL	5.5813 mL
100 mM	0.0558 mL	0.2791 mL	0.5581 mL	2.7906 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc