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Phenyl-benzothiazole

Name: Phenyl-benzothiazole
Brand: TargetMol
SKU: T22636
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22636Cas No. 92-36-4

Alias Dehydrothio-p-toluidine, 4-(6-methyl-1,3-benzothiazol-2-yl)aniline, 2-(p-Aminophenyl)-6-methylbenzothiazole, 2-(4-Aminophenyl)-6-methylbenzothiazole

Phenyl-benzothiazole (2-(4-Aminophenyl)-6-methylbenzothiazole) is an azole for proteomics research.

Phenyl-benzothiazole

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Purity: 99.58%

Catalog No. T22636Alias Dehydrothio-p-toluidine, 4-(6-methyl-1,3-benzothiazol-2-yl)aniline, 2-(p-Aminophenyl)-6-methylbenzothiazole, 2-(4-Aminophenyl)-6-methylbenzothiazoleCas No. 92-36-4

Phenyl-benzothiazole (2-(4-Aminophenyl)-6-methylbenzothiazole) is an azole for proteomics research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.58%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Phenyl-benzothiazole AI Summary

Phenyl-benzothiazole exhibits a log P value of 2.4, indicating moderate lipophilicity, and demonstrates a high binding affinity (Ki = 9.5 nM) for Amyloid beta 1-40 aggregates, suggesting potential bioactivity related to amyloid beta interactions. It induces cell cycle arrest in human BCC cells, causing an accumulation at the sub G1 phase at a concentration of 4 µM when incubated for 4 hours followed by UV irradiation, with an observed activity of 13.4% after 24 hours. The compound shows varying bioactivities in several assays, such as moderate cytotoxicity to Streptococcus and SK(-)GAS Group A Streptococcus (EC50 values >150,000 nM), inhibition of human Jumonji Domain Containing 2E (potency 14,125.4 nM), activation of Rab9 promoter (223.9 nM), and Leishmania Mexicana Pyruvate Kinase (12,589.3 nM). It also inhibits tau fibril formation and human alpha-Glucosidase from spleen homogenate (potencies 5,623.4 nM to 31,622.8 nM), along with other bioactivities affecting various enzymes and pathways. Notably, Phenyl-benzothiazole has a selectivity ratio of 200.0 for human triosephosphate isomerase over Trypanosoma cruzi triosephosphate isomerase, indicating specific inhibition preferences..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenyl-benzothiazole (2-(4-Aminophenyl)-6-methylbenzothiazole) is an azole for proteomics research.
Synonyms	Dehydrothio-p-toluidine, 4-(6-methyl-1,3-benzothiazol-2-yl)aniline, 2-(p-Aminophenyl)-6-methylbenzothiazole, 2-(4-Aminophenyl)-6-methylbenzothiazole

Chemical Properties

Molecular Weight	240.32
Formula	C₁₄H₁₂N₂S
Cas No.	92-36-4
Smiles	CC1=CC=C2N=C(SC2=C1)C1=CC=C(N)C=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (62.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1611 mL	20.8056 mL	41.6112 mL	208.0559 mL
5 mM	0.8322 mL	4.1611 mL	8.3222 mL	41.6112 mL
10 mM	0.4161 mL	2.0806 mL	4.1611 mL	20.8056 mL
20 mM	0.2081 mL	1.0403 mL	2.0806 mL	10.4028 mL
50 mM	0.0832 mL	0.4161 mL	0.8322 mL	4.1611 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc