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Biricodar dicitrate

Catalog No. T67790 CAS 174254-13-8

Synonyms: VX 710, VX 710-3

Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Biricodar dicitrate, CAS 174254-13-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 518.00
5 mg	In stock	$ 1,170.00
25 mg	In stock	$ 1,920.00
50 mg	In stock	$ 2,380.00
100 mg	6-8weeks	$ 3,100.00

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Purity: 98.67%

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Description	Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.
Targets&IC50	P-gp:0.75uM(EC50), Iodoaryl azido-prazosin:0.55 μM(EC50)
In vitro	Biricodar exhibits activity against both P-glycoprotein (Pgp) and MRP-1, enhancing drug uptake and retention while reversing drug resistance mediated by wild-type BCRP (BCRPR482). In Pgp-expressing 8226/Dox6 cells, biricodar increases the uptake of mitoxantrone and daunorubicin by 55% and 100%, respectively. It enhances their retention by 100% and 60%, respectively, and boosts their cytotoxicity by 3.1- and 6.9-fold, respectively. Furthermore, biricodar has similar effects on HL60/Adr cells (MRP-1) and 8226/MR20 cells (BCRP(R482)), but it has little impact on MCF7 AdVP3000 cells (BCRP(R482T))[1]. VX-710, a non-macrocyclic pipecolinate derivative binding to the FK506 receptor protein, has been shown to restore sensitivity in various multidrug-resistant cells, including myeloma, melanoma, carcinoma, and leukemia[2]. Additionally, biricodar effectively inhibits the photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azido-prazosin, with EC50 values of 0.75 and 0.55 μM[3].

Synonyms	VX 710, VX 710-3
Molecular Weight	987.95
Formula	C46H57N3O21
CAS No.	174254-13-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Minderman H, et al. VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Clin Cancer Res. 2004 Mar 1;10(5):1826-34. 2. Yanagisawa T, et al. BIRICODAR (VX-710; Incel): an effective chemosensitizer in neuroblastoma. Br J Cancer. 1999 Jun;80(8):1190-6. 3. Germann UA, et al. Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro. Anticancer Drugs. 1997 Feb;8(2):125-40.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

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Keywords

Biricodar dicitrate 174254-13-8 Neuroscience NF-Κb NF-κB AChR VX 710 Biricodar VX710 VX-710 VX 710-3 Biricodar Dicitrate inhibitor inhibit

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