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PD-L1/Nampt-IN-1

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Catalog No. T212272Cas No. 3054043-85-2

PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.

PD-L1/Nampt-IN-1

PD-L1/Nampt-IN-1

😃Good
Catalog No. T212272Cas No. 3054043-85-2
PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mgInquiry10-14 weeks10-14 weeks
50 mgInquiry10-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.
In vitro
PD-L1/Nampt-IN-1 (Compound T8) (0.5-5 μM) inhibits the interaction between PD-1 and PD-L1 in a dose-dependent manner, achieving an inhibition rate of 76.3% at a concentration of 5 μM.
In vivo
PD-L1/Nampt-IN-1 (Compound T8) administered orally at 50 mg/kg for 14 days significantly enhances tumor growth inhibition in the B16-F10 murine tumor model, attributed to the activation of the tumor immune microenvironment. In tumors, the compound accumulates at 1133.6 ng/mL at 8 hours and crosses the blood-brain barrier with 81.86 ng/mL at 1 hour.
Chemical Properties
Molecular Weight452.55
FormulaC28H28N4O2
Cas No.3054043-85-2
SmilesO=C(NCCNCC=1C=CC(=NC1OC)C=2C=CC=C(C=3C=CC=CC3)C2C)C=4C=NC=CC4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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