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IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
(Synonyms: MGC18216, MGC142172, MGC142170, JTK13, IGFR, IGFIR, IGF-I receptor, IGF-I R, IGF-1R, IGF1R, CD221) Copy Product InfoSynonyms: MGC18216, MGC142172, MGC142170, JTK13, IGFR, IGFIR, IGF-I receptor, IGF-I R, IGF-1R, IGF1R, CD221
Catalog No. TMPK-00658 Copy Product Info
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) and the accession number is G7P9I7.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $58 | 6-8 weeks | 6-8 weeks | |
| 10 μg | $92 | 6-8 weeks | 6-8 weeks | |
| 20 μg | $148 | 6-8 weeks | 6-8 weeks | |
| 50 μg | $289 | 6-8 weeks | 6-8 weeks | |
| 100 μg | $487 | 6-8 weeks | 6-8 weeks | |
| 200 μg | $883 | 6-8 weeks | 6-8 weeks | |
| 500 μg | $1,950 | 6-8 weeks | 6-8 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) and the accession number is G7P9I7. |
| Species | Cynomolgus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | G7P9I7 |
| Construction | Glu31-Asn908 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | MGC18216, MGC142172, MGC142170, JTK13, IGFR, IGFIR, IGF-I receptor, IGF-I R, IGF-1R, IGF1R, CD221 |
| Research Background |
| Molecular Weight | 80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result. |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) chemical structure | IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) molecular weight
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