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Abatacept
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Catalog No. T10218Cas No. 332348-12-6
Alias CTLA4lg, BMS-188667
Abatacept is a soluble recombinant fusion protein consisting of the extracellular domain of human CTLA-4 and the Fc portion of human IgG1. It binds with high affinity to CD80 and CD86 on antigen-presenting cells, specifically blocking the CD28-mediated costimulatory signal required for T-cell activation. Abatacept is widely used to investigate rheumatoid arthritis, autoimmune responses, and immune dysregulation caused by LRBA deficiency.
Abatacept
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Purity: 95%
Catalog No. T10218Alias CTLA4lg, BMS-188667Cas No. 332348-12-6
Abatacept is a soluble recombinant fusion protein consisting of the extracellular domain of human CTLA-4 and the Fc portion of human IgG1. It binds with high affinity to CD80 and CD86 on antigen-presenting cells, specifically blocking the CD28-mediated costimulatory signal required for T-cell activation. Abatacept is widely used to investigate rheumatoid arthritis, autoimmune responses, and immune dysregulation caused by LRBA deficiency.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $813 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
Appearance:Liquid
Color:Transparent
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| Description | Abatacept is a soluble recombinant fusion protein consisting of the extracellular domain of human CTLA-4 and the Fc portion of human IgG1. It binds with high affinity to CD80 and CD86 on antigen-presenting cells, specifically blocking the CD28-mediated costimulatory signal required for T-cell activation. Abatacept is widely used to investigate rheumatoid arthritis, autoimmune responses, and immune dysregulation caused by LRBA deficiency. |
| In vitro | In co-culture assays of primary CD4+ T cells and APCs, Abatacept (100 ug/mL) blocked the CD80/86:CD28 costimulatory axis and inhibited T-cell proliferation [3]. In ex vivo analysis of cells from patients with LRBA deficiency, Abatacept modulated CTLA-4 expression levels and restored regulatory T cell function [1]. |
| In vivo | In a rat model of collagen-induced arthritis, subcutaneous administration of Abatacept (0.1, 1, 10 mg/kg) led to dose-dependent reduction in paw edema [2]. In mouse T-cell priming models, systemic administration of Abatacept (0.5 mg/mouse) inhibited antigen-specific T-cell activation and expansion [3]. |
| Animal Research | Animal Model: Male Lewis rats (6-9 weeks old) with weights of 150-175 g. Dosage: 10 mg/kg (i.v.), 20 mg/kg (s.c. single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29. Administration: i.v. or s.c. [2] |
| Synonyms | CTLA4lg, BMS-188667 |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Cas No. | 332348-12-6 |
| Relative Density. | no data available |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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