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Chitin synthase inhibitor 4

Name: Chitin synthase inhibitor 4
Brand: TargetMol
SKU: T61147
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61147Cas No. 2755847-31-3

Chitin synthase inhibitor 4 is a chitin synthase (CHS) inhibitor with antimicrobial activity.Chitin synthase inhibitor 4 is a CHS-based compound and a candidate fungicide.

Chitin synthase inhibitor 4

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Purity: 99.8%

Catalog No. T61147Cas No. 2755847-31-3

Chitin synthase inhibitor 4 is a chitin synthase (CHS) inhibitor with antimicrobial activity.Chitin synthase inhibitor 4 is a CHS-based compound and a candidate fungicide.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$100	In Stock	In Stock
25 mg	$205	In Stock	In Stock
50 mg	$298	In Stock	In Stock
100 mg	$413	-	In Stock
200 mg	$548	-	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.8%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Chitin synthase inhibitor 4 is a chitin synthase (CHS) inhibitor with antimicrobial activity.Chitin synthase inhibitor 4 is a CHS-based compound and a candidate fungicide.
In vitro	Chitin synthase inhibitor 4 (compound 4fh), at a concentration of 50 μM for 3 hours, significantly inhibits chitin synthase and polyoxin D, with respective inhibition rates of 68.08% and 63.84%. Demonstrating effective antifungal properties, it achieves EC50 values of 0.71 and 2.47 μg/mL against V. mali and S. sclerotiorum, respectively. At a higher concentration of 50 μg/mL, it shows remarkable inhibition efficacy against the same fungi, with inhibition rates of 90.3% and 88.7%, respectively. At 1 μg/mL, it notably disrupts hyphal growth, leading to abnormal growth characterized by decreased cell content, cell wall degradation, and plasmolysis.
In vivo	Chitin synthase inhibitor 4 (compound 4fh) (Oral gavage; Rat with Salmonella typhimurium) has low acute toxicity, with no carcinogenic and mutagenic toxicity risk.[1] Chitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity.[1]

Chemical Properties

Molecular Weight	346.36
Formula	C₂₀H₁₅FN₄O
Cas No.	2755847-31-3
Smiles	Fc1c(Oc2ccccc2C#N)ncnc1N1CCCc2ccccc12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (158.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8872 mL	14.4358 mL	28.8717 mL	144.3585 mL
5 mM	0.5774 mL	2.8872 mL	5.7743 mL	28.8717 mL
10 mM	0.2887 mL	1.4436 mL	2.8872 mL	14.4358 mL
20 mM	0.1444 mL	0.7218 mL	1.4436 mL	7.2179 mL
50 mM	0.0577 mL	0.2887 mL	0.5774 mL	2.8872 mL
100 mM	0.0289 mL	0.1444 mL	0.2887 mL	1.4436 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc