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Anti-ASGR1 Antibody (8E417)

😃Good
Catalog No. TMAY-01152
Alias HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR

Anti-ASGR1 Antibody (8E417) is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Antibody (8E417) can be used in WB,ELISA(Cap),IP.

Anti-ASGR1 Antibody (8E417)

Anti-ASGR1 Antibody (8E417)

😃Good
Catalog No. TMAY-01152Alias HL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR
Anti-ASGR1 Antibody (8E417) is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Antibody (8E417) can be used in WB,ELISA(Cap),IP.
Pack SizePriceAvailabilityQuantity
20 μL$92 7-10 days
100 μL$292 7-10 days
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Product Introduction

Bioactivity
Description
Anti-ASGR1 Antibody (8E417) is a Rabbit antibody targeting ASGR1. Anti-ASGR1 Antibody (8E417) can be used in WB,ELISA(Cap),IP.
AliasHL-1, CLEC4H1, asialoglycoprotein receptor 1, ASGPR1, ASGPR
Ig Type
Monoclonal Rabbit IgG
Clone
8E417
Reactivity
Human
Verified Activity
1. Anti-ASGR1 rabbit monoclonal antibody at 1:500 dilution.

-Lane A: HepG2 Whole Cell lysate.

-Lysates/proteins at 30 μg per lane.

-Secondary

-Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

-Developed using the Odyssey technique.

-Performed under reducing conditions.

-Predicted band size:33 kDa.

-Observed band size:43 kDa.

2. ASGR1 was immunoprecipitated using:

-Lane A:0.5 mg HepG2 Whole Cell Lysate.

-4 µL anti-ASGR1 rabbit monoclonal antibody and 60 μg of Immunomagnetic beads Protein A/G.

-Primary antibody:

-Anti-ASGR1 rabbit monoclonal antibody, at 1:100 dilution.

-Secondary antibody:

-Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

-Developed using the ECL technique.

-Performed under reducing conditions.

-Predicted band size: 33 kDa.

-Observed band size:43 kDa
Application
WB,ELISA(Cap),IP
Recommended Dose
WB: 1:500-1:2000; IP: 1-4 μL/mg of lysate; ELISA(Cap): 1:250-1:2000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human ASGPR1 (rh ASGPR1 ; TMPY-02702; P07306; Gln62-Leu291).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundThe asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human ASGPR1 protein (TMPY-02702)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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