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OXF BD 02
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Catalog No. T23115Cas No. 1429129-68-9
Alias OXFBD02
OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.
OXF BD 02
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Purity: 98.25%
Catalog No. T23115Alias OXFBD02Cas No. 1429129-68-9
OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $100 | In Stock | In Stock | |
| 5 mg | $247 | In Stock | In Stock | |
| 10 mg | $372 | In Stock | In Stock | |
| 25 mg | $689 | In Stock | In Stock | |
| 50 mg | $986 | In Stock | In Stock | |
| 100 mg | $1,320 | In Stock | In Stock | |
| 500 mg | $2,660 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.25%
Appearance:Solid
Color:White
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Product Introduction
OXF BD 02 AI Summary
OXF BD 02 exhibits cytotoxicity against various human cell lines with high IC50 values (>10000.0 nM) for HeLa and U2OS cells at 24 hours, and for NCI-H1975 and A549 cells at 72 hours. However, it has a much lower IC50 value of 794.0 nM for MV4-11 cells at 72 hours, indicating a more potent effect on this cell line. The compound shows growth inhibition of cancer cell lines such as A498, MCF7, HT-29, and HL-60(TB) with GI50 values between 1250.0 nM and 4540.0 nM. It inhibits the BRD4 bromodomain 1 with an IC50 of 384.0 nM. In terms of metabolic stability, OXF BD 02 has a short half-life (T1/2 = 0.6633 hr) in human liver microsomes and moderate intrinsic clearance (CL = 34.8 mL.min-1.g-1). Additionally, it shows activity against various bromodomain proteins in BROMOscan assays and demonstrates TGI (Total Growth Inhibition) at higher concentrations. The compound also inhibits human HDAC6 enzyme activity with a -20.51% inhibition using a commercial peptide substrate and a 2.55% inhibition using a custom peptide substrate..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | OXF BD 02 is a potent and selective BRD4(1) inhibitor (IC50: 382 nM) with anticancer and anti-inflammatory activity. |
| Targets&IC50 | BRD4:382 nM |
| Synonyms | OXFBD02 |
| Molecular Weight | 295.33 |
| Formula | C18H17NO3 |
| Cas No. | 1429129-68-9 |
| Smiles | CC=1C(C2=CC(C(O)C3=CC=CC=C3)=CC(O)=C2)=C(C)ON1 |
| Relative Density. | 1.233 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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