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DuP-697

Name: DuP-697
Brand: TargetMol
SKU: T15181
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15181Cas No. 88149-94-4

DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects.

DuP-697

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Purity: 99.92%

Catalog No. T15181Cas No. 88149-94-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$262	In Stock	In Stock
50 mg	$389	In Stock	In Stock
100 mg	$572	In Stock	In Stock
200 mg	$813	-	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects.
Targets&IC50	COX-2 (human):10 nM, COX-1 (human):800 nM
In vitro	METHODS: DuP-697 (0, 12.5, 25, 50, 100, 200 μM, 36 hours) was used to treat K562 or CML cell lines. The effects on cell growth were evaluated by MTT assay, and the effects on cell apoptosis were detected by flow cytometry. RESULTS DuP-697 significantly inhibited the growth of K562 cells and primary CML cells with an IC50 value of 31.7 μM, and induced cell apoptosis in a concentration-dependent manner. [2]
In vivo	METHODS: DuP 697 (5 mg/kg, intraperitoneal injection) was used to treat rats 1 hour before thrombin injection to investigate its neurotoxic effects on dopaminergic neuronal degeneration in the substantia nigra (SN) of rats. RESULTS The loss of TH-ip neurons was partially attenuated in the SN of rats treated with DuP-697. [2]

Chemical Properties

Molecular Weight	411.31
Formula	C₁₇H₁₂BrFO₂S₂
Cas No.	88149-94-4
Smiles	CS(=O)(=O)c1ccc(cc1)-c1cc(Br)sc1-c1ccc(F)cc1
Relative Density.	1.514g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (109.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4313 mL	12.1563 mL	24.3126 mL	121.5628 mL
5 mM	0.4863 mL	2.4313 mL	4.8625 mL	24.3126 mL
10 mM	0.2431 mL	1.2156 mL	2.4313 mL	12.1563 mL
20 mM	0.1216 mL	0.6078 mL	1.2156 mL	6.0781 mL
50 mM	0.0486 mL	0.2431 mL	0.4863 mL	2.4313 mL
100 mM	0.0243 mL	0.1216 mL	0.2431 mL	1.2156 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc