Shopping Cart

Remove All
Your shopping cart is currently empty

A2A receptor antagonist 1

Name: A2A receptor antagonist 1
Brand: TargetMol
SKU: T37792
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T37792Cas No. 443103-97-7

Alias CPI-444 analog, A2A receptor antagonist 1

A2A receptor antagonist 1 (CPI-444 analog) is an inhibitor of the adenosine A2A receptor and A1 receptor with Ki values of 4 nM and 264 nM, respectively.

A2A receptor antagonist 1

🥰Excellent

Purity: 99.93%

Catalog No. T37792Alias CPI-444 analog, A2A receptor antagonist 1Cas No. 443103-97-7

A2A receptor antagonist 1 (CPI-444 analog) is an inhibitor of the adenosine A2A receptor and A1 receptor with Ki values of 4 nM and 264 nM, respectively.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$58	In Stock
10 mg	$93	In Stock
25 mg	$195	In Stock
50 mg	$298	In Stock
100 mg	$442	In Stock
500 mg	$930	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.93%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	A2A receptor antagonist 1 (CPI-444 analog) is an inhibitor of the adenosine A2A receptor and A1 receptor with Ki values of 4 nM and 264 nM, respectively.
Targets&IC50	A1 receptor:264 nM (Ki), A2A receptor:4 nM (Ki)
In vitro	A2A receptor anyagonist 1 is a potent adenosine A2A receptor antagonist, selective over the A1 receptor and demonstrate its binding activity with Ki values of 4 and 264 nM, respectively. [1]
Synonyms	CPI-444 analog, A2A receptor antagonist 1

Chemical Properties

Molecular Weight	309.3
Formula	C₁₆H₁₂FN₅O
Cas No.	443103-97-7
Smiles	Nc1nc(-c2ccco2)c2cnn(Cc3ccccc3F)c2n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (161.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2331 mL	16.1655 mL	32.3311 mL	161.6554 mL
5 mM	0.6466 mL	3.2331 mL	6.4662 mL	32.3311 mL
10 mM	0.3233 mL	1.6166 mL	3.2331 mL	16.1655 mL
20 mM	0.1617 mL	0.8083 mL	1.6166 mL	8.0828 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL	3.2331 mL
100 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6166 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc