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p-Toluic Acid

Name: p-Toluic Acid
Brand: TargetMol
SKU: Fr14438
Rating: 4.5 (1 reviews)

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Catalog No. Fr14438Cas No. 99-94-5

Alias 4-Methylbenzoic acid

p-Toluic Acid (4-Methylbenzoic acid) belongs to the class of organic compounds known as benzoic acids. 4-Methylbenzoic acid has been primarily detected in saliva. Within the cell, 4-methylbenzoic acid is primarily located in the cytoplasm.

p-Toluic Acid

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Purity: 99.73%

Catalog No. Fr14438Alias 4-Methylbenzoic acidCas No. 99-94-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

p-Toluic Acid AI Summary

p-Toluic Acid demonstrates a diverse range of bioactivities and physicochemical properties. It has been evaluated for its electronic effects with a Hammett constant of -0.17, suggesting specific reactivity useful in chemical processes. Toxicologically, it has an isotoxic concentration log 1/LD50 of -1.66. The compound’s physicochemical attributes include a partition coefficient logD of 2.26 and pKa values of 4.36 and 4.37, indicating its dissociation constants. Bioactivity assays reveal that p-Toluic Acid inhibits human kidney thiopurine methyltransferase (TPMT) with an IC50 of 288403.15 nM. It also enhances SMN2 splice variant expression with a potency of 100.0 nM and inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 25118.9 nM. Furthermore, it acts as an agonist of the antioxidant response element (ARE) signaling pathway with a potency of 21131.7 nM and exhibits antihemorrhagic activity by inhibiting Protobothrops flavoviridis venom-induced lesion formation with an IC50 of 220.0 nM. In addition, p-Toluic Acid displays bioactivity as an inhibitor of Sir2p in yeast with an MIC of 800,000.0 nM, and as an inhibitor of chymotrypsin with a log1/Ki value of 2.43. It shows low affinity to sigma1 and sigma2 receptors (Ki values > 10000.0 nM) and minimal cytotoxicity against human MCF7 cells (IC50 > 100000.0 nM), indicating low bioactivity at these sites. The compound has been noted for its potential in various research and therapeutic applications due to its array of biological activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	p-Toluic Acid (4-Methylbenzoic acid) belongs to the class of organic compounds known as benzoic acids. 4-Methylbenzoic acid has been primarily detected in saliva. Within the cell, 4-methylbenzoic acid is primarily located in the cytoplasm.
Synonyms	4-Methylbenzoic acid

Chemical Properties

Molecular Weight	136.15
Formula	C₈H₈O₂
Cas No.	99-94-5
Smiles	CC1=CC=C(C=C1)C(O)=O
Relative Density.	1.06 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (403.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3448 mL	36.7242 mL	73.4484 mL	367.2420 mL
5 mM	1.4690 mL	7.3448 mL	14.6897 mL	73.4484 mL
10 mM	0.7345 mL	3.6724 mL	7.3448 mL	36.7242 mL
20 mM	0.3672 mL	1.8362 mL	3.6724 mL	18.3621 mL
50 mM	0.1469 mL	0.7345 mL	1.4690 mL	7.3448 mL
100 mM	0.0734 mL	0.3672 mL	0.7345 mL	3.6724 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc