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Englerin A

Name: Englerin A
Brand: TargetMol
SKU: T38484
Rating: 4.5 (1 reviews)

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Catalog No. T38484Cas No. 1094250-15-3

Alias (-)-Englerin A

Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells.

Englerin A

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Catalog No. T38484Alias (-)-Englerin ACas No. 1094250-15-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells.
Targets&IC50	TRPC4 (human):11.2 nM (EC50), TRPC5 (human):7.6 nM (EC50)
In vitro	Englerin A (50 nM) activates TRPC4/C5 channels, leading to an increase in intracellular calcium and membrane depolarization[3].
In vivo	Athymic mice bearing 786-0 tumor xenografts were treated with Englerin A (5mg/kg i.p., daily except Sunday), and the results showed that Englerin A significantly inhibited tumor growth during the treatment period[4].
Synonyms	(-)-Englerin A

Chemical Properties

Molecular Weight	442.54
Formula	C₂₆H₃₄O₆
Cas No.	1094250-15-3
Smiles	[H][C@@]12CC[C@@H](C)[C@@]1([H])[C@H](OC(=O)\C=C\c1ccccc1)[C@@]1(C[C@@H](OC(=O)CO)[C@@]2(C)O1)C(C)C

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 20 mg/mL (45.19 mM), Sonication is recommended.

Solution Preparation Table

Methanol

	1mg	5mg	10mg	50mg
1 mM	2.2597 mL	11.2984 mL	22.5968 mL	112.9841 mL
5 mM	0.4519 mL	2.2597 mL	4.5194 mL	22.5968 mL
10 mM	0.2260 mL	1.1298 mL	2.2597 mL	11.2984 mL
20 mM	0.1130 mL	0.5649 mL	1.1298 mL	5.6492 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc