store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells.
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Description | Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells. |
Targets&IC50 | TRPC4 (human):11.2 nM (EC50), TRPC5 (human):7.6 nM (EC50) |
In vitro | Englerin A (50 nM) activates TRPC4/C5 channels, leading to an increase in intracellular calcium and membrane depolarization[3]. |
In vivo | Athymic mice bearing 786-0 tumor xenografts were treated with Englerin A (5mg/kg i.p., daily except Sunday), and the results showed that Englerin A significantly inhibited tumor growth during the treatment period[4]. |
Synonyms | (-)-Englerin A |
Molecular Weight | 442.54 |
Formula | C26H34O6 |
CAS No. | 1094250-15-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: 20 mg/mL (45.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Englerin A 1094250-15-3 Membrane transporter/Ion channel TRP/TRPV Channel (-)-Englerin A inhibitor inhibit