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Substance P(1-7) TFA

Name: Substance P(1-7) TFA
Brand: TargetMol
SKU: T75963
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75963Cas No. 2828433-22-1

Substance P(1-7) TFA is a fragment of neuropeptide P (SP) with anti-nociceptive activity. It prevents morphine-induced spontaneous pain behavior through the spinal NMDA-NO cascade, and can be used in research on neurological diseases.

Substance P(1-7) TFA

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Purity: 98.23%

Catalog No. T75963Cas No. 2828433-22-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	-	In Stock
2 mg	$55	-	In Stock
5 mg	$89	-	In Stock
10 mg	$147	-	In Stock
25 mg	$289	-	In Stock
50 mg	$428	-	In Stock
100 mg	$623	-	In Stock
200 mg	$878	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.23%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS HNMR FNMR

Product Introduction

Bioactivity

Description	Substance P(1-7) TFA is a fragment of neuropeptide P (SP) with anti-nociceptive activity. It prevents morphine-induced spontaneous pain behavior through the spinal NMDA-NO cascade, and can be used in research on neurological diseases.
In vivo	Injection of low doses of Substance P(1-7) TFA (1.0-4.0 pM) and concomitant administration of SP or SP(5-11) (0.1 nM) significantly inhibited aversive behaviors triggered by SP or SP(5-11). These findings suggest that endogenously generated Substance P(1-7) may play an important function in the spinal cord by modulating the action of SP or SP(5-11). [1]

Chemical Properties

Molecular Weight	1014.06
Formula	C₄₃H₆₆F₃N₁₃O₁₂
Cas No.	2828433-22-1
Smiles	C(C(O)=O)(F)(F)F.C([C@@H](NC(=O)[C@H]1N(C([C@H](CCCNC(=N)N)N)=O)CCC1)CCCCN)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCC2
Sequence	Arg-Pro-Lys-Pro-Gln-Gln-Phe
Sequence Short	RPKPQQF

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (39.45 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.9861 mL	4.9307 mL	9.8613 mL	49.3067 mL
5 mM	0.1972 mL	0.9861 mL	1.9723 mL	9.8613 mL
10 mM	0.0986 mL	0.4931 mL	0.9861 mL	4.9307 mL
20 mM	0.0493 mL	0.2465 mL	0.4931 mL	2.4653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc