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K34C

Name: K34C
Brand: TargetMol
SKU: T41151
Price: 175 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T41151Cas No. 939769-93-4

K34C is a selective inhibitor of Integrin α5β1, which inhibits cell survival and migration, promotes apoptosis in U87MG cells, inhibits TGFβ-induced invasion, and reduces cell adhesion to fibronectin.

K34C

🥰Excellent

Purity: 99.66%

Catalog No. T41151Cas No. 939769-93-4

Pack Size	Price	Availability
1 mg	$175	In Stock
5 mg	$436	In Stock
10 mg	$636	In Stock
25 mg	$996	In Stock
50 mg	$1,330	In Stock

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Batch Information

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Purity:99.66%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

Methods:
To evaluate the effect of K34C on apoptosis in U87MG glioblastoma cells, cells were treated with 20 μM K34C in combination with 1 μM Ellipticine for 24 or 48 hours. Apoptosis was assessed by measuring the sub-G1 cell population.
Results:
K34C combined with Ellipticine significantly induced apoptosis in U87MG cells, as evidenced by a marked increase in the sub-G1 population, suggesting that K34C enhances Ellipticine-induced apoptotic effects [1].

Chemical Properties

Molecular Weight	447.53
Formula	C₂₆H₂₉N₃O₄
Cas No.	939769-93-4
Smiles	C([C@H](NC(=O)C1=C(C)C=CC=C1C)C(O)=O)C2=CC=C(OCCCNC3=CC=CC=N3)C=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (268.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2345 mL	11.1724 mL	22.3449 mL	111.7244 mL
5 mM	0.4469 mL	2.2345 mL	4.4690 mL	22.3449 mL
10 mM	0.2234 mL	1.1172 mL	2.2345 mL	11.1724 mL
20 mM	0.1117 mL	0.5586 mL	1.1172 mL	5.5862 mL
50 mM	0.0447 mL	0.2234 mL	0.4469 mL	2.2345 mL
100 mM	0.0223 mL	0.1117 mL	0.2234 mL	1.1172 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc