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K34C
🥰Excellent
Catalog No. T41151Cas No. 939769-93-4
K34C is a selective inhibitor of Integrin α5β1, which inhibits cell survival and migration, promotes apoptosis in U87MG cells, inhibits TGFβ-induced invasion, and reduces cell adhesion to fibronectin.
K34C
🥰Excellent
Purity: 99.66%
Catalog No. T41151Cas No. 939769-93-4
K34C is a selective inhibitor of Integrin α5β1, which inhibits cell survival and migration, promotes apoptosis in U87MG cells, inhibits TGFβ-induced invasion, and reduces cell adhesion to fibronectin.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $175 | In Stock | |
| 5 mg | $436 | In Stock | |
| 10 mg | $636 | In Stock | |
| 25 mg | $996 | In Stock | |
| 50 mg | $1,330 | In Stock |
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Purity:99.66%
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Product Introduction
Bioactivity
Chemical Properties
| Description | K34C is a selective inhibitor of Integrin α5β1, which inhibits cell survival and migration, promotes apoptosis in U87MG cells, inhibits TGFβ-induced invasion, and reduces cell adhesion to fibronectin. |
| In vitro | Methods: To evaluate the effect of K34C on apoptosis in U87MG glioblastoma cells, cells were treated with 20 μM K34C in combination with 1 μM Ellipticine for 24 or 48 hours. Apoptosis was assessed by measuring the sub-G1 cell population. Results: K34C combined with Ellipticine significantly induced apoptosis in U87MG cells, as evidenced by a marked increase in the sub-G1 population, suggesting that K34C enhances Ellipticine-induced apoptotic effects [1]. |
| Molecular Weight | 447.53 |
| Formula | C26H29N3O4 |
| Cas No. | 939769-93-4 |
| Smiles | C([C@H](NC(=O)C1=C(C)C=CC=C1C)C(O)=O)C2=CC=C(OCCCNC3=CC=CC=N3)C=C2 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (268.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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