IGF2R Protein, Human, Recombinant (hFc)

Name: IGF2R Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-07125
Price: 77 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: MPRI, MPR300, MPR1, MPR 300, M6P-R, M6P/IGF2R, IGF2R, CI-MPR, CIMPR, CI-M6PR, CD222) Copy Product Info

Synonyms: MPRI, MPR300, MPR1, MPR 300, M6P-R, M6P/IGF2R, IGF2R, CI-MPR, CIMPR, CI-M6PR, CD222

Catalog No. TMPY-07125 Copy Product Info

IGF2R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P11717.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$77	-	In Stock
10 µg	$126	-	In Stock
20 µg	$198	7-10 days	7-10 days
50 µg	$397	7-10 days	7-10 days
100 µg	$796	7-10 days	7-10 days
200 µg	$1,200	7-10 days	7-10 days
500 µg	$2,590	7-10 days	7-10 days
1 mg	$5,280	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized TROP-2 Protein, Human, Recombinant (His) (Cat#TMPY-01262) at 2 μg/mL (100 μL/well) can bind IGF2R Protein, Human, Recombinant (hFc) (Cat#TMPY-07125), with a linear range of 0.16-4.0 μg/mL.
Description	IGF2R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P11717.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P11717
Construction	A DNA sequence encoding the Human Igf2r (P11717) (Met1-Asp1365) was expressed with the Fc region of human IgG1 at the C-terminus.
Protein Purity	≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, 8% Glycerol, 5% Trehalose, 0.02% Tween 80, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Please refer to the lot-specific COA.
Synonyms	MPRI, MPR300, MPR1, MPR 300, M6P-R, M6P/IGF2R, IGF2R, CI-MPR, CIMPR, CI-M6PR, CD222
Research Background	Among IGFs, insulinlike growth factor 2 (IGF2) is a key regulator of cell growth, survival, migration and differentiation. The type 2 IGF receptor (IGF2R) modulates circulating and tissue levels of IGF2 by targeting it to lysosomes for degradation. The extracytoplasmic region of IGF2R has three binding sites: one for IGF2 in domain 11 and two for Man-6-P in domains 3, 5 and 9. Binding between IGF2 and IGF2R induces the lysosomal degradation of IGF2. IGF2R serves to clear IGF2 from the circulation or degrade excess circulating IGF2. Soluble IGF2R can affect the size of some organs exclusively by reducing the biological activity of IGF2.

Chemical Properties

Molecular Weight

173.22 kDa (predicted); 196.1 kDa (reducing contition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.