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TBT1

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Catalog No. T61042Cas No. 52535-76-9

TBT1 is a novel MsbA transporter protein inhibitor and MsbA ATPase stimulator, which inhibits the synthesis of ATP-dependent transporter proteins in the lipopolysaccharide synthesis pathway.TBT1 possesses antimicrobial activity, which inhibits Salmonella, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, and it can be used in the study of bacterial infections.

TBT1

TBT1

😃Good
Purity: 99.27%
Catalog No. T61042Cas No. 52535-76-9
TBT1 is a novel MsbA transporter protein inhibitor and MsbA ATPase stimulator, which inhibits the synthesis of ATP-dependent transporter proteins in the lipopolysaccharide synthesis pathway.TBT1 possesses antimicrobial activity, which inhibits Salmonella, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, and it can be used in the study of bacterial infections.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$93In StockIn Stock
5 mg$228In StockIn Stock
10 mg$372In StockIn Stock
25 mg$689In StockIn Stock
50 mg$1,090In StockIn Stock
100 mg$1,780In StockIn Stock
200 mg$2,380-In Stock
1 mL x 10 mM (in DMSO)$253In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.27%
Appearance:Solid
Color:Yellow
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Product Introduction

Bioactivity
Description
TBT1 is a novel MsbA transporter protein inhibitor and MsbA ATPase stimulator, which inhibits the synthesis of ATP-dependent transporter proteins in the lipopolysaccharide synthesis pathway.TBT1 possesses antimicrobial activity, which inhibits Salmonella, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, and it can be used in the study of bacterial infections.
Chemical Properties
Molecular Weight335.81
FormulaC16H14ClNO3S
Cas No.52535-76-9
SmilesOC(=O)c1c(NC(=O)c2ccc(Cl)cc2)sc2CCCCc12
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (297.79 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9779 mL14.8894 mL29.7787 mL148.8937 mL
5 mM0.5956 mL2.9779 mL5.9557 mL29.7787 mL
10 mM0.2978 mL1.4889 mL2.9779 mL14.8894 mL
20 mM0.1489 mL0.7445 mL1.4889 mL7.4447 mL
50 mM0.0596 mL0.2978 mL0.5956 mL2.9779 mL
100 mM0.0298 mL0.1489 mL0.2978 mL1.4889 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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