Shopping Cart

Your shopping cart is currently empty

ND-646

Name: ND-646
Brand: TargetMol
SKU: TQ0243
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. TQ0243Cas No. 1434639-57-2

ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

ND-646

😃Good

Purity: 98.64%

Catalog No. TQ0243Cas No. 1434639-57-2

ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$322	In Stock	In Stock
25 mg	$547	In Stock	In Stock
50 mg	$787	In Stock	In Stock
100 mg	$1,060	In Stock	In Stock
200 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$247	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.64%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
Targets&IC50	ACC1 (human):3.5 nM , ACC2 (human):4.1 nM
In vivo	ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo.?Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth.?When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC.

Chemical Properties

Molecular Weight	568.64
Formula	C₂₈H₃₂N₄O₇S
Cas No.	1434639-57-2
Smiles	COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(N)=O)-c1ncco1)OC1CCOCC1
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (167.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7586 mL	8.7929 mL	17.5858 mL	87.9291 mL
5 mM	0.3517 mL	1.7586 mL	3.5172 mL	17.5858 mL
10 mM	0.1759 mL	0.8793 mL	1.7586 mL	8.7929 mL
20 mM	0.0879 mL	0.4396 mL	0.8793 mL	4.3965 mL
50 mM	0.0352 mL	0.1759 mL	0.3517 mL	1.7586 mL
100 mM	0.0176 mL	0.0879 mL	0.1759 mL	0.8793 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc