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Sinapine thiocyanate

🥰Excellent
Catalog No. T3392Cas No. 7431-77-8

Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer's disease (AD).

Sinapine thiocyanate
Other Forms of Sinapine thiocyanate:
SinapineT2S120018696-26-9
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Sinapine thiocyanate

🥰Excellent
Purity: 99.86%
Catalog No. T3392Cas No. 7431-77-8
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer's disease (AD).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$55In StockIn Stock
25 mg$90In StockIn Stock
50 mg$129In StockIn Stock
100 mg$229In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.86%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer's disease (AD).
Chemical Properties
Molecular Weight368.45
FormulaC16H24NO5·CNS
Cas No.7431-77-8
Smiles[S-]C#N.COc1cc(C=CC(=O)OCC[N+](C)(C)C)cc(OC)c1O
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (135.7 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.43 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7141 mL13.5704 mL27.1407 mL135.7036 mL
5 mM0.5428 mL2.7141 mL5.4281 mL27.1407 mL
10 mM0.2714 mL1.3570 mL2.7141 mL13.5704 mL
20 mM0.1357 mL0.6785 mL1.3570 mL6.7852 mL
50 mM0.0543 mL0.2714 mL0.5428 mL2.7141 mL
100 mM0.0271 mL0.1357 mL0.2714 mL1.3570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Sinapine thiocyanateSinapine ThiocyanateSinapineradio-protectiveP-gp (P-glycoprotein)P-gpPgpP-glycoproteinParkinson'smyastheniaMultidrug resistance protein 1MDR1InhibitorinhibitgravisdiseasecruciferousCluster of differentiation 243Cholinesterase (ChE)CD243ataxiaanti-tumoranti-oxidantanti-inflammatoryanti-angiogenicAlzheimer'sAChEacetylcholinesteraseABCB1
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