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HPK1-IN-4

Catalog No. T40350 CAS 2739844-28-9

Synonyms: HPK1-IN-4

HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.

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HPK1-IN-4, CAS 2739844-28-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 147.00
5 mg	In stock	$ 372.00
10 mg	In stock	$ 556.00
25 mg	In stock	$ 896.00
50 mg	In stock	$ 1,220.00
100 mg	In stock	$ 1,650.00
500 mg	In stock	$ 3,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Purity: 97.2%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
Targets&IC50	HPK1:0.061 nM (IC50)

Synonyms	HPK1-IN-4
Molecular Weight	434.49
Formula	C23H26N6O3
CAS No.	2739844-28-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (207.1 mM), when pH is adjusted to 4 with HCl. Sonication is recommended.

References and Literature

1. Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 ; 12(4):653-661.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HPK1-IN-4 2739844-28-9 MAPK HPK1 IN 4 HPK-1-IN-4 HPK1IN4 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.