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HPK1-IN-4

Name: HPK1-IN-4
Brand: TargetMol
SKU: T40350
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40350Cas No. 2739844-28-9

Alias HPK1-IN-4

HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.

HPK1-IN-4

🥰Excellent

Purity: 97.2%

Catalog No. T40350Alias HPK1-IN-4Cas No. 2739844-28-9

HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.

Pack Size	Price	Availability
1 mg	$132	In Stock
5 mg	$328	In Stock
10 mg	$496	In Stock
25 mg	$868	In Stock
50 mg	$1,190	In Stock
100 mg	$1,630	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock

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Batch Information

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Purity:97.2%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
Targets&IC50	HPK1:0.061 nM (IC50)
Synonyms	HPK1-IN-4

Chemical Properties

Molecular Weight	434.49
Formula	C₂₃H₂₆N₆O₃
Cas No.	2739844-28-9
Smiles	COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2CO)n1
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (207.1 mM), when pH is adjusted to 4 with HCl. Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3015 mL	11.5077 mL	23.0155 mL	115.0774 mL
5 mM	0.4603 mL	2.3015 mL	4.6031 mL	23.0155 mL
10 mM	0.2302 mL	1.1508 mL	2.3015 mL	11.5077 mL
20 mM	0.1151 mL	0.5754 mL	1.1508 mL	5.7539 mL
50 mM	0.0460 mL	0.2302 mL	0.4603 mL	2.3015 mL
100 mM	0.0230 mL	0.1151 mL	0.2302 mL	1.1508 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc