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CB-103

Name: CB-103
Brand: TargetMol
SKU: T12246
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12246Cas No. 218457-67-1

CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.

CB-103

🥰Excellent

Purity: 99.44%

Catalog No. T12246Cas No. 218457-67-1

CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.

Pack Size	Price	Availability
100 mg	$33	In Stock
200 mg	$48	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.44%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
In vitro	CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines, and exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines[2].
In vivo	CB-103inhibits growth of GSI/Mab resistant triple negative breast cancer, andexhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors[3].

Chemical Properties

Molecular Weight	242.32
Formula	C₁₅H₁₈N₂O
Cas No.	218457-67-1
Smiles	CC(C)(C)C1=CC=C(OC2=NC=C(N)C=C2)C=C1
Relative Density.	1.09g/cm3
Color	Orange
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (206.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1268 mL	20.6339 mL	41.2677 mL	206.3387 mL
5 mM	0.8254 mL	4.1268 mL	8.2535 mL	41.2677 mL
10 mM	0.4127 mL	2.0634 mL	4.1268 mL	20.6339 mL
20 mM	0.2063 mL	1.0317 mL	2.0634 mL	10.3169 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	4.1268 mL
100 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0634 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc