FOLR1 Protein, Human, Recombinant (His) V2

Name: FOLR1 Protein, Human, Recombinant (His) V2
Brand: TargetMol
SKU: TMPY-01815U
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP) Copy Product Info

Synonyms: FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP

Catalog No. TMPY-01815U Copy Product Info

FOLR1 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P15328.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$48	-	In Stock
10 µg	$75	-	In Stock
20 µg	$118	-	In Stock
50 µg	$229	-	In Stock
100 µg	$386	7-10 days	7-10 days
200 µg	$682	7-10 days	7-10 days
500 µg	$1,430	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:Greater than 95% as determined by reducing SDS-PAGE.

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Human FOLR1-His at 1 μg/ml (100 μl/well) can bind Anti-Human FOLR1 mAb.The ED50 of Anti-Human FOLR1 mAb is 0.626 ng/ml. Loaded Anti-Human FOLR1 mAb-Fc on Protein A Biosensor, can bind Human FOLR1-His with an affinity constant of 12.1 nM as determined in BLI assay.
Description	FOLR1 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P15328.
Species	Human
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	P15328
Construction	Arg25-Ser234
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP
Research Background	Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

Chemical Properties

Molecular Weight

25.7 kDa (Predicted); 28-38 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.