Immobilized Human FOLR1-His at 1 μg/ml (100 μl/well) can bind Anti-Human FOLR1 mAb.The ED50 of Anti-Human FOLR1 mAb is 0.626 ng/ml.
Loaded Anti-Human FOLR1 mAb-Fc on Protein A Biosensor, can bind Human FOLR1-His with an affinity constant of 12.1 nM as determined in BLI assay.

FOLR1 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P15328.

Human

HEK293 Cells

FOLR,folate receptor 1 (adult),Folate Binding Protein,FBP

Arg25-Ser234

> 95% as determined by SDS-PAGE

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.