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Ganoderic acid G

Name: Ganoderic acid G
Brand: TargetMol
SKU: T3S1149
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S1149Cas No. 98665-22-6

Ganoderic acid G is isolated from the surface of Ganoderma lucidum tube layer.

Ganoderic acid G

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Purity: 99.86%

Catalog No. T3S1149Cas No. 98665-22-6

Ganoderic acid G is isolated from the surface of Ganoderma lucidum tube layer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$76	In Stock	In Stock
5 mg	$178	In Stock	In Stock
10 mg	$282	In Stock	In Stock
25 mg	$475	In Stock	In Stock
50 mg	$695	-	In Stock
100 mg	$988	-	In Stock
1 mL x 10 mM (in DMSO)	$233	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Color:White

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COA HNMR LCMS

Product Introduction

Ganoderic acid G AI Summary

Ganoderic acid G has been studied for various biological activities. It exhibits weak inhibition of recombinant human aldose reductase using dl-glyceraldehyde as a substrate, with an IC50 value greater than 187900.0 nM. The compound shows cytotoxicity against several cell lines: human SGC7901, Bel7402, and mouse P388 cells with an IC50 of 7250.0 nM, human HeLa cells with an IC50 of 101000.0 nM, and human HepG2 cells with an IC50 of 85600.0 nM over 48 hours as assessed by MTT assay. Ganoderic acid G also demonstrates weak inhibition of alpha-glucosidase activity using sucrose as a substrate, with an IC50 value greater than 600,000.0 nM. In addition to its cytotoxic properties, the compound exhibits anti-inflammatory activity by inhibiting LPS-induced NO production in mouse BV2 cells with an IC50 of 5770.0 nM and shows significant cytotoxicity against LPS-induced mouse BV2 cells with 95.24% cell viability after 24 hours. Chromatography analysis reveals a retention time of 46.5 minutes for Ganoderic acid G..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Ganoderic acid G is isolated from the surface of Ganoderma lucidum tube layer.

Chemical Properties

Molecular Weight	532.67
Formula	C₃₀H₄₄O₈
Cas No.	98665-22-6
Smiles	[H][C@@]12C[C@H](O)C3=C(C(=O)[C@@H](O)[C@]4(C)[C@H](CC(=O)[C@@]34C)[C@H](C)CC(=O)CC(C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C
Relative Density.	1.27g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12 mg/mL (22.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8773 mL	9.3867 mL	18.7733 mL	93.8667 mL
5 mM	0.3755 mL	1.8773 mL	3.7547 mL	18.7733 mL
10 mM	0.1877 mL	0.9387 mL	1.8773 mL	9.3867 mL
20 mM	0.0939 mL	0.4693 mL	0.9387 mL	4.6933 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc