Shopping Cart
Remove All
Your shopping cart is currently empty
L-838417
Copy Product Info
🥰Excellent
Catalog No. T19702Cas No. 286456-42-6
Alias L838417, L 838417
L-838417 is a GABAA receptor subtype-selective benzodiazepine site-selective ligand and GABAA receptor-positive modulator.L-838417 is a selective partial agonist of the α2, α3, and α5 subtypes and an antagonist of the α1 subtype and is used in the study of anxiety disorders.
L-838417
Copy Product Info🥰Excellent
Purity: 99.70%
Catalog No. T19702Alias L838417, L 838417Cas No. 286456-42-6
L-838417 is a GABAA receptor subtype-selective benzodiazepine site-selective ligand and GABAA receptor-positive modulator.L-838417 is a selective partial agonist of the α2, α3, and α5 subtypes and an antagonist of the α1 subtype and is used in the study of anxiety disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 5 mg | $196 | In Stock | In Stock | |
| 10 mg | $227 | In Stock | In Stock | |
| 25 mg | $548 | In Stock | In Stock | |
| 50 mg | $828 | In Stock | In Stock | |
| 100 mg | $1,230 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.70%
Appearance:Solid
Color:White to Yellow
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-838417 is a GABAA receptor subtype-selective benzodiazepine site-selective ligand and GABAA receptor-positive modulator.L-838417 is a selective partial agonist of the α2, α3, and α5 subtypes and an antagonist of the α1 subtype and is used in the study of anxiety disorders. |
| Targets&IC50 | α5β3γ2:2.25 nM (Ki), α1β3γ2:0.79 nM (Ki), α4β3γ2:267 nM (Ki), α2β3γ2:0.67 nM (Ki), α6β3γ2:2183 nM (Ki), α3β3γ2:1.67 nM (Ki) |
| In vivo | In unfamiliar environments, adult rats: at a dose of 1.0 mg/kg L-838417, social avoidance shifted to social preference and increased social probing. Adolescent rats: at 2.0 mg/kg L-838417 dose, elimination of social avoidance but no increase in social probing. [2] In familiar environments (after repeated restraint stress), reversal of stress-induced anxiety effects, regardless of age, at 0.5 mg/kg L-838417 dose. ≥1.0 mg/kg L-838417 dose, reduced social probing, possibly related to inhibition of motor function. [2] |
| Synonyms | L838417, L 838417 |
| Molecular Weight | 399.4 |
| Formula | C19H19F2N7O |
| Cas No. | 286456-42-6 |
| Smiles | FC=1C=CC(F)=C(C1)C2=NN=C3C=C(C(=NN32)OCC4=NC=NN4C)C(C)(C)C |
| Relative Density. | 1.40 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (50.08 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2 mg/mL (5.01 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy L-838417 | purchase L-838417 | L-838417 cost | order L-838417 | L-838417 chemical structure | L-838417 in vivo | L-838417 formula | L-838417 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.