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PROTAC BRD4 ligand-1

🥰Excellent
Catalog No. T12551Cas No. 2313230-51-0

PROTAC BRD4 ligand-1, a component of Protac GNE-987, is a ligand for BRD4 and acts as an inhibitor of BET.

PROTAC BRD4 ligand-1

PROTAC BRD4 ligand-1

🥰Excellent
Purity: 99.28%
Catalog No. T12551Cas No. 2313230-51-0
PROTAC BRD4 ligand-1, a component of Protac GNE-987, is a ligand for BRD4 and acts as an inhibitor of BET.
Pack SizePriceAvailabilityQuantity
1 mg$125In Stock
5 mg$313In Stock
10 mg$522In Stock
25 mg$987In Stock
50 mg$1,660In Stock
100 mg$2,390In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.28%
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Product Introduction

Bioactivity
Description
PROTAC BRD4 ligand-1, a component of Protac GNE-987, is a ligand for BRD4 and acts as an inhibitor of BET.
Targets&IC50
BRD 4 BD1:41.8 nM, EOL-1 AML cells:0.03 nM (DC50)
Chemical Properties
Molecular Weight500.47
FormulaC23H18F2N4O5S
Cas No.2313230-51-0
SmilesCn1cc2-c3cc(CS(C)(=O)=O)c(cc3N(Cc3c[nH]c(c23)c1=O)c1ncc(F)cc1F)C(O)=O
Relative Density.1.68 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.5 mg/mL (9.0 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9981 mL9.9906 mL19.9812 mL99.9061 mL
5 mM0.3996 mL1.9981 mL3.9962 mL19.9812 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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