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Isoliquiritin

Name: Isoliquiritin
Brand: TargetMol
SKU: T5S0331
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0331Cas No. 5041-81-6

Alias Neoisoliquritin

1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dependent pathway and shows crosstalk between Akt activities.

Isoliquiritin

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Purity: 99.88%

Catalog No. T5S0331Alias NeoisoliquritinCas No. 5041-81-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$249	In Stock	In Stock
50 mg	$373	-	In Stock
100 mg	$549	-	In Stock
500 mg	$1,170	-	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Isoliquiritin AI Summary

Isoliquiritin demonstrates multifaceted inhibitory bioactivity. Specifically, it functions as an inhibitor of the Spanish flu (A/Bervig_Mission/1/18) neuraminidase, with an IC50 value of 124,000 nM in one assay and a Ki value of 94,000 nM in a noncompetitive inhibition assay. Furthermore, it effectively inhibits human recombinant aldose reductase, exhibiting an IC50 of 720 nM. Additionally, Isoliquiritin inhibits the PTP1B enzyme (source unspecified) using p-nitrophenyl phosphate as a substrate at a concentration of 100 µM, with observed inhibition of less than 50%. Lastly, it inhibits the human DPP4 enzyme with an IC50 value of 26,920 nM, as determined using the H-Gly-Pro-AMC peptide substrate in a fluorimetric assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dependent pathway and shows crosstalk between Akt activities.
Synonyms	Neoisoliquritin

Chemical Properties

Molecular Weight	418.39
Formula	C₂₁H₂₂O₉
Cas No.	5041-81-6
Smiles	OC[C@H]1O[C@@H](Oc2ccc(\C=C\C(=O)c3ccc(O)cc3O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Relative Density.	1.528g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 237.5 mg/mL (567.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3901 mL	11.9506 mL	23.9011 mL	119.5057 mL
5 mM	0.4780 mL	2.3901 mL	4.7802 mL	23.9011 mL
10 mM	0.2390 mL	1.1951 mL	2.3901 mL	11.9506 mL
20 mM	0.1195 mL	0.5975 mL	1.1951 mL	5.9753 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc