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Anti-Gremlin-1 Antibody (3L967)
😃Good
Catalog No. TMAH-00512
Alias GREM1
Anti-Gremlin-1 Antibody (3L967) is an antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (3L967) can be used in ELISA, IHC.
Anti-Gremlin-1 Antibody (3L967)
Anti-Gremlin-1 Antibody (3L967)
😃Good
Catalog No. TMAH-00512Alias GREM1
Anti-Gremlin-1 Antibody (3L967) is an antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (3L967) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Gremlin-1 Antibody (3L967) is an antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (3L967) can be used in ELISA, IHC. |
| Synonyms | GREM1 |
| Ig Type | hIgG1 |
| Clone | 3L967 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-00512 diluted at 1：100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. 2. IHC image of TMAH-00512 diluted at 1：100 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| Application | |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human GREM1 Protein |
| Antigen Species | Human |
| Gene Name | GREM1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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