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Contezolid

🥰Excellent
Catalog No. T28109Cas No. 1112968-42-9
Alias MRX-I, MRXI, MRX I

Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria.

Contezolid

Contezolid

🥰Excellent
Purity: 99.41%
Catalog No. T28109Alias MRX-I, MRXI, MRX ICas No. 1112968-42-9
Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$228In StockIn Stock
5 mg$562In StockIn Stock
10 mg$828In StockIn Stock
25 mg$1,650In StockIn Stock
50 mg$2,320In StockIn Stock
1 mL x 10 mM (in DMSO)$619In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.41%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria.
In vitro
Contezolid activity against MRSA strains (MIC50/90, 0.5/1 mg/liter; highest MIC, 1 mg/liter) was equivalent to that observed against MSSA strains (MIC50/90, 0.5/1 mg/liter; highest MIC, 2 mg/liter). [1]
In vivo
The ED50s of Contezolid against S. aureus ATCC 29213, 15, ATCC 33591, Mu50, and 0850 were 7.98, 5.74, 2.36, 2.50, and 3.71 mg/kg. Five different doses (5.0, 10.0, 20.0, 40.0, and 80.0 mg/kg) of Contezolid and the reference compound linezolid were orally administered twice, at 2 h and 6 h after infection, respectively. [2]
SynonymsMRX-I, MRXI, MRX I
Chemical Properties
Molecular Weight408.33
FormulaC18H15F3N4O4
Cas No.1112968-42-9
SmilesO=C1N(C[C@H](CNC=2C=CON2)O1)C3=C(F)C(F)=C(C(F)=C3)N4CCC(=O)C=C4
Relative Density.1.528 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (244.90 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.8 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4490 mL12.2450 mL24.4900 mL122.4500 mL
5 mM0.4898 mL2.4490 mL4.8980 mL24.4900 mL
10 mM0.2449 mL1.2245 mL2.4490 mL12.2450 mL
20 mM0.1224 mL0.6122 mL1.2245 mL6.1225 mL
50 mM0.0490 mL0.2449 mL0.4898 mL2.4490 mL
100 mM0.0245 mL0.1224 mL0.2449 mL1.2245 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ContezolidantibioticAntibacterial
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