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Contezolid

Name: Contezolid
Brand: TargetMol
SKU: T28109
Price: 228 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28109Cas No. 1112968-42-9

Alias MRX-I, MRXI, MRX I

Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria.

Contezolid

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Purity: 99.41%

Catalog No. T28109Alias MRX-I, MRXI, MRX ICas No. 1112968-42-9

Pack Size	Price	Availability
1 mg	$228	In Stock
5 mg	$562	In Stock
10 mg	$828	In Stock
25 mg	$1,650	In Stock
50 mg	$2,320	In Stock
1 mL x 10 mM (in DMSO)	$619	In Stock

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Batch Information

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Purity:99.41%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria.
In vitro	Contezolid activity against MRSA strains (MIC50/90, 0.5/1 mg/liter; highest MIC, 1 mg/liter) was equivalent to that observed against MSSA strains (MIC50/90, 0.5/1 mg/liter; highest MIC, 2 mg/liter). [1]
In vivo	The ED50s of Contezolid against S. aureus ATCC 29213, 15, ATCC 33591, Mu50, and 0850 were 7.98, 5.74, 2.36, 2.50, and 3.71 mg/kg. Five different doses (5.0, 10.0, 20.0, 40.0, and 80.0 mg/kg) of Contezolid and the reference compound linezolid were orally administered twice, at 2 h and 6 h after infection, respectively. [2]
Synonyms	MRX-I, MRXI, MRX I

Chemical Properties

Molecular Weight	408.33
Formula	C₁₈H₁₅F₃N₄O₄
Cas No.	1112968-42-9
Smiles	O=C1N(C[C@H](CNC=2C=CON2)O1)C3=C(F)C(F)=C(C(F)=C3)N4CCC(=O)C=C4
Relative Density.	1.528 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (244.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4490 mL	12.2450 mL	24.4900 mL	122.4500 mL
5 mM	0.4898 mL	2.4490 mL	4.8980 mL	24.4900 mL
10 mM	0.2449 mL	1.2245 mL	2.4490 mL	12.2450 mL
20 mM	0.1224 mL	0.6122 mL	1.2245 mL	6.1225 mL
50 mM	0.0490 mL	0.2449 mL	0.4898 mL	2.4490 mL
100 mM	0.0245 mL	0.1224 mL	0.2449 mL	1.2245 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc