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Contezolid (Synonyms: MRX-I, MRXI, MRX I)

Name: Contezolid
Brand: TargetMol
SKU: T28109
Price: 228 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T28109 Copy Product Info

Purity: 99.41%

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Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria.

Contezolid

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Catalog No. T28109

Synonyms MRX-I, MRXI, MRX I

Cas No. 1112968-42-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$228	In Stock	In Stock
5 mg	$562	In Stock	In Stock
10 mg	$828	In Stock	In Stock
25 mg	$1,650	In Stock	In Stock
50 mg	$2,320	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$619	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.41%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria.
In vitro	Contezolid activity against MRSA strains (MIC50/90, 0.5/1 mg/liter; highest MIC, 1 mg/liter) was equivalent to that observed against MSSA strains (MIC50/90, 0.5/1 mg/liter; highest MIC, 2 mg/liter). [1]
In vivo	The ED50s of Contezolid against S. aureus ATCC 29213, 15, ATCC 33591, Mu50, and 0850 were 7.98, 5.74, 2.36, 2.50, and 3.71 mg/kg. Five different doses (5.0, 10.0, 20.0, 40.0, and 80.0 mg/kg) of Contezolid and the reference compound linezolid were orally administered twice, at 2 h and 6 h after infection, respectively. [2]
Synonyms	MRX-I, MRXI, MRX I

Chemical Properties

Molecular Weight	408.33
Formula	C₁₈H₁₅F₃N₄O₄
Cas No.	1112968-42-9
Smiles	O=C1N(C[C@H](CNC=2C=CON2)O1)C3=C(F)C(F)=C(C(F)=C3)N4CCC(=O)C=C4
Relative Density.	1.528 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (244.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4490 mL	12.2450 mL	24.4900 mL	122.4500 mL
5 mM	0.4898 mL	2.4490 mL	4.8980 mL	24.4900 mL
10 mM	0.2449 mL	1.2245 mL	2.4490 mL	12.2450 mL
20 mM	0.1224 mL	0.6122 mL	1.2245 mL	6.1225 mL
50 mM	0.0490 mL	0.2449 mL	0.4898 mL	2.4490 mL
100 mM	0.0245 mL	0.1224 mL	0.2449 mL	1.2245 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc