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Anti-PINK1 Polyclonal Antibody
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Catalog No. TMAB-01542
Alias Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK
Anti-PINK1 Polyclonal Antibody is a Rabbit antibody targeting PINK1. Anti-PINK1 Polyclonal Antibody can be used in WB.
Anti-PINK1 Polyclonal Antibody
Anti-PINK1 Polyclonal Antibody
😃Good
Catalog No. TMAB-01542Alias Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK
Anti-PINK1 Polyclonal Antibody is a Rabbit antibody targeting PINK1. Anti-PINK1 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $221 | 7-10 days | |
| 100 μL | $374 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-PINK1 Polyclonal Antibody is a Rabbit antibody targeting PINK1. Anti-PINK1 Polyclonal Antibody can be used in WB. |
| Synonyms | Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Sample: Lane 1: Mouse Muscle tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Rat Heart tissue lysates Lane 4: Rat Muscle tissue lysates Lane 5: Rat Cerebrum tissue lysates Lane 6: Human U-2 OS cell lysates Primary: Anti-PINK1 (TMAB-01542) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 64 kDa Observed band size: 58 kDa 2. Sample: Lane 1: Human HeLa cell lysates Lane 2: Human A431 cell lysates Lane 3: Human U-2OS cell lysates Primary: Anti-PINK1 (TMAB-01542) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 64 kDa Observed band size: 60 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol. |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human PINK1 |
| Antigen Species | Human |
| Gene Name | PINK1 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase PINK1, mitochondrial |
| Uniprot ID | |
| Biology Area | Cardiac metabolism,Mitochondrial markers,Mitophagy fission and fusion,Neurodegenerative disease,Parkinson's disease,Mitochondrial,Other Kinases |
| Function | Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN . Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 . Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form . Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). |
| Molecular Weight | Theoretical: 64 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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