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FX-06

Catalog No. T78562 CAS 88650-17-3

Synonyms: Fibrin-derived peptide Bβ15-42

FX-06 (Fibrin-derived peptide Bβ15-42) is a peptide derived from the fibrin Bbeta chain. It interacts with VE-cadherin to inhibit leukocyte transmigration and initiate VE-cadherin-mediated signaling pathways. This compound has applications in researching ischemia/reperfusion injury and Dengue shock syndrome (DSS) [1] [2] [4].

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FX-06, CAS 88650-17-3

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Biological Description

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Description	FX-06 (Fibrin-derived peptide Bβ15-42) is a peptide derived from the fibrin Bbeta chain. It interacts with VE-cadherin to inhibit leukocyte transmigration and initiate VE-cadherin-mediated signaling pathways. This compound has applications in researching ischemia/reperfusion injury and Dengue shock syndrome (DSS) [1] [2] [4].
In vitro	FX-06 (50 μM, 3 days) suppresses D2HG synthesis in HEK-293T cells expressing mutant IDH1 R132H [2].
In vivo	FX06, administered intravenously at 2.4 mg/kg as a bolus, notably enhances pulmonary and circulatory function in a porcine model of hemorrhagic shock and reperfusion [3]. The same dosage, given intraperitoneally twice daily, increases survival rates and mitigates capillary leakage in Dengue shock syndrome mouse models [4]. When administered at 3.6 mg/kg intravenously, FX06 safeguards against ischemia/reperfusion (I/R)-induced renal damage in mice, promoting epithelial cell proliferation and facilitating tissue repair [5].

Synonyms	Fibrin-derived peptide Bβ15-42
Molecular Weight	3039.41
Formula	C133H216N44O38
CAS No.	88650-17-3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

FX-06 88650-17-3 Fibrin-derived peptide Bβ15-42 inhibitor inhibit

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