LMP744

Name: LMP744
Brand: TargetMol
SKU: T11872
Rating: 4.5 (1 reviews)

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Catalog No. T11872Cas No. 308246-52-8

Alias NSC706744, MJ-III65

LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

LMP744

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Catalog No. T11872Alias NSC706744, MJ-III65Cas No. 308246-52-8

LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$736	6-8 weeks	6-8 weeks
50 mg	$957	6-8 weeks	6-8 weeks
100 mg	$1,440	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
In vitro	LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].The GI50 value of LMP744 for NCI60 cells is 0.1 μM[2].
In vivo	LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against FaDu tumor xenografts??and human A253 without significant toxicity[1].
Synonyms	NSC706744, MJ-III65

Chemical Properties

Molecular Weight	452.46
Formula	C₂₄H₂₄N₂O₇
Cas No.	308246-52-8
Smiles	COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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