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CDK12-IN-3

🥰Excellent
Catalog No. T14990Cas No. 2220184-50-7

CDK12-IN-3 is a selective and potent CDK12 inhibitor with anti-tumor activity, which can be used to study malignant tumors.

CDK12-IN-3

CDK12-IN-3

🥰Excellent
Purity: 99.85%
Catalog No. T14990Cas No. 2220184-50-7
CDK12-IN-3 is a selective and potent CDK12 inhibitor with anti-tumor activity, which can be used to study malignant tumors.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$132In StockIn Stock
5 mg$328In StockIn Stock
10 mg$538In StockIn Stock
25 mg$1,130In StockIn Stock
50 mg$1,890In StockIn Stock
100 mg$2,500In StockIn Stock
1 mL x 10 mM (in DMSO)$363In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.85%
ee:100%
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COA CSFC FNMR HNMR LCMS

Product Introduction

Bioactivity
Description
CDK12-IN-3 is a selective and potent CDK12 inhibitor with anti-tumor activity, which can be used to study malignant tumors.
Targets&IC50
CDK12:491 nM
In vitro
CDK12-IN-3 is a highly selective inhibitor of CDK12, capable of effectively inhibiting the phosphorylation of Ser2 sites on the CTD repeat domain of RNA Polymerase II, exerting growth inhibitory effects on OV90 cells, and demonstrating acute cytotoxicity against THP1 cells[1].
Chemical Properties
Molecular Weight470.52
FormulaC23H28F2N8O
Cas No.2220184-50-7
SmilesCC(C)n1cnc2c(NCc3nc4ccc(F)c(F)c4[nH]3)nc(nc12)N1CCCC[C@H]1CCO
Relative Density.1.51 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (425.06 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.63 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1253 mL10.6265 mL21.2531 mL106.2654 mL
5 mM0.4251 mL2.1253 mL4.2506 mL21.2531 mL
10 mM0.2125 mL1.0627 mL2.1253 mL10.6265 mL
20 mM0.1063 mL0.5313 mL1.0627 mL5.3133 mL
50 mM0.0425 mL0.2125 mL0.4251 mL2.1253 mL
100 mM0.0213 mL0.1063 mL0.2125 mL1.0627 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

CDK12-IN-3CDK-12-IN-3CDK12IN3CDK12 IN 3CDK12
Related Tags: buy CDK12-IN-3 | purchase CDK12-IN-3 | CDK12-IN-3 cost | order CDK12-IN-3 | CDK12-IN-3 chemical structure | CDK12-IN-3 in vitro | CDK12-IN-3 formula | CDK12-IN-3 molecular weight
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