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Desvenlafaxine

Name: Desvenlafaxine
Brand: TargetMol
SKU: T1580
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1580Cas No. 93413-62-8

Alias WY 45233 Succinate, O-Desmethylvenlafaxine

Desvenlafaxine (O-Desmethylvenlafaxine) is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive agent.

Desvenlafaxine

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Purity: 99.81%

Catalog No. T1580Alias WY 45233 Succinate, O-DesmethylvenlafaxineCas No. 93413-62-8

Pack Size	Price	Availability
50 mg	$30	In Stock
100 mg	$40	In Stock
500 mg	$73	In Stock
1 g	$106	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Purity:99.81%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Desvenlafaxine (O-Desmethylvenlafaxine) is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive agent.
Targets&IC50	Norepinephrine:558.4 nM(Ki), 5-HT:40.2 nM(Ki)
In vitro	In male rats, the oral administration of Desvenlafaxine Succinate penetrates the brain and hypothalamus, significantly increasing extracellular norepinephrine levels.
In vivo	Desvenlafaxine Succinate inhibits the neuronal uptake of serotonin (5-HT) and norepinephrine (NE) with IC50 values of 47.3 nM and 531.3 nM, respectively. It exhibits weak binding affinity to human dopamine (DA) transporters at a concentration of 100 μM.
Synonyms	WY 45233 Succinate, O-Desmethylvenlafaxine

Chemical Properties

Molecular Weight	263.38
Formula	C₁₆H₂₅NO₂
Cas No.	93413-62-8
Smiles	C(CN(C)C)(C1(O)CCCCC1)C2=CC=C(O)C=C2
Relative Density.	1.115 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 3 mg/mL (11.39 mM), Sonication is recommended.

DMSO: 16.67 mg/mL (63.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7968 mL	18.9840 mL	37.9680 mL	189.8398 mL
5 mM	0.7594 mL	3.7968 mL	7.5936 mL	37.9680 mL
10 mM	0.3797 mL	1.8984 mL	3.7968 mL	18.9840 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1898 mL	0.9492 mL	1.8984 mL	9.4920 mL
50 mM	0.0759 mL	0.3797 mL	0.7594 mL	3.7968 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc