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Anti-L-selectin Antibody (4Y137)
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Catalog No. TMAY-02084
Alias selectin L
Anti-L-selectin Antibody (4Y137) is a Mouse antibody targeting L-selectin. Anti-L-selectin Antibody (4Y137) can be used in ELISA,FCM.
Anti-L-selectin Antibody (4Y137)
Anti-L-selectin Antibody (4Y137)
😃Good
Catalog No. TMAY-02084Alias selectin L
Anti-L-selectin Antibody (4Y137) is a Mouse antibody targeting L-selectin. Anti-L-selectin Antibody (4Y137) can be used in ELISA,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA, FCM Reactivity: Human |
| Alias | selectin L |
| Ig Type | Mouse IgG1 |
| Clone | 4Y137 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human SELL(CD62L) expression on human whole blood lymphocytes. Cells were stained with purified anti-Human SELL(CD62L), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | ELISA,FCM |
| Recommended Dose | ELISA: 1:1000-1:2000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD62L / L-Selectin / SELL (rh CD62L / L-Selectin / SELL; TMPY-02024; P14151-1; Met1-Asn332). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development. |
| Conjucates | Unconjugated |
| Others Formats | APC/PerCP/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human CD62L / L-Selectin / SELL Protein (TMPY-02024) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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