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Anti-TNFSF11 Monoclonal Antibody (1K503)
(Synonyms: TRANCE, TNLG6B, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254) Copy Product Info
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Synonyms: TRANCE, TNLG6B, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254
Catalog No. TMAT-0599 Copy Product Info
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Anti-TNFSF11 Monoclonal Antibody (1K503) is a Mouse antibody targeting TNFSF11. Anti-TNFSF11 Monoclonal Antibody (1K503) can be used in WB,IHC,IF,FCM.
Anti-TNFSF11 Monoclonal Antibody
(1K503)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-TNFSF11 Monoclonal Antibody (1K503) is a Mouse antibody targeting TNFSF11. Anti-TNFSF11 Monoclonal Antibody (1K503) can be used in WB,IHC,IF,FCM. |
| Synonyms | TRANCE, TNLG6B, sOdf, RANKL, OPTB2, OPGL, ODF, hRANKL2, CD254 |
| Ig Type | IgG1 |
| Clone | 1K503 |
| Reactivity | Human,Mouse,Rat,Monkey,Rabbit |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/100-1/500; IF: 1/50-1/500; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human TNFSF11 (AA: 74-308) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | TNFSF11 |
| Gene ID | |
| Protein Name | Tumor necrosis factor ligand superfamily member 11 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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